Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 610765..611468 Replicon chromosome
Accession NZ_CP100511
Organism Klebsiella pneumoniae strain LH50-a

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag NLZ12_RS02915 Protein ID WP_126800543.1
Coordinates 611127..611468 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NLZ12_RS02910 Protein ID WP_254541277.1
Coordinates 610765..611106 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ12_RS02875 (NLZ12_02875) 605918..606793 + 876 WP_254541274.1 GTPase family protein -
NLZ12_RS02880 (NLZ12_02880) 607036..607770 + 735 WP_254541275.1 WYL domain-containing protein -
NLZ12_RS02885 (NLZ12_02885) 607787..608239 + 453 WP_254541276.1 hypothetical protein -
NLZ12_RS02890 (NLZ12_02890) 608311..608784 + 474 WP_060175535.1 hypothetical protein -
NLZ12_RS02895 (NLZ12_02895) 608904..609725 + 822 WP_126800547.1 DUF932 domain-containing protein -
NLZ12_RS02900 (NLZ12_02900) 609756..610199 + 444 WP_126800546.1 antirestriction protein -
NLZ12_RS02905 (NLZ12_02905) 610212..610754 + 543 WP_126800545.1 DNA repair protein RadC -
NLZ12_RS02910 (NLZ12_02910) 610765..611106 + 342 WP_254541277.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NLZ12_RS02915 (NLZ12_02915) 611127..611468 + 342 WP_126800543.1 TA system toxin CbtA family protein Toxin
NLZ12_RS02920 (NLZ12_02920) 611592..612560 + 969 WP_072202751.1 IS5 family transposase -
NLZ12_RS02925 (NLZ12_02925) 612726..614759 - 2034 WP_126800542.1 hypothetical protein -
NLZ12_RS02930 (NLZ12_02930) 615354..616222 - 869 Protein_577 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 581277..615512 34235
- flank IS/Tn - - 611637..612560 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13023.09 Da        Isoelectric Point: 10.6066

>T250709 WP_126800543.1 NZ_CP100511:611127-611468 [Klebsiella pneumoniae]
MKTLPATTQRAAKLYLSPVAVWQMLLARLLEQHHGLILNDTPFSDEAVIQEHINAGINLADAVNFLMEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12832.50 Da        Isoelectric Point: 6.6248

>AT250709 WP_254541277.1 NZ_CP100511:610765-611106 [Klebsiella pneumoniae]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYMADRASITGKFSNAEYLKLVEIFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References