Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 520341..520857 Replicon chromosome
Accession NZ_CP100511
Organism Klebsiella pneumoniae strain LH50-a

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NLZ12_RS02540 Protein ID WP_004178374.1
Coordinates 520573..520857 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NLZ12_RS02535 Protein ID WP_254541262.1
Coordinates 520341..520583 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ12_RS02520 (NLZ12_02520) 516369..517109 + 741 WP_002886899.1 KDGP aldolase family protein -
NLZ12_RS02525 (NLZ12_02525) 517176..518330 + 1155 WP_032415878.1 lactonase family protein -
NLZ12_RS02530 (NLZ12_02530) 518353..520263 + 1911 WP_009486549.1 PRD domain-containing protein -
NLZ12_RS02535 (NLZ12_02535) 520341..520583 + 243 WP_254541262.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NLZ12_RS02540 (NLZ12_02540) 520573..520857 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ12_RS02545 (NLZ12_02545) 520861..521325 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NLZ12_RS02550 (NLZ12_02550) 521654..523792 - 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
NLZ12_RS02555 (NLZ12_02555) 524149..524892 - 744 WP_159308131.1 MurR/RpiR family transcriptional regulator -
NLZ12_RS02560 (NLZ12_02560) 524895..525068 - 174 WP_004146781.1 hypothetical protein -
NLZ12_RS02565 (NLZ12_02565) 525198..525461 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T250708 WP_004178374.1 NZ_CP100511:520573-520857 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT250708 WP_254541262.1 NZ_CP100511:520341-520583 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIVENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References