Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1828..2363 Replicon plasmid pLH50-c-A
Accession NZ_CP100501
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name relE Uniprot ID V0VJJ7
Locus tag NLZ13_RS27040 Protein ID WP_000222760.1
Coordinates 2076..2363 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag NLZ13_RS27035 Protein ID WP_001132900.1
Coordinates 1828..2079 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS27025 (NLZ13_27030) 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
NLZ13_RS27030 (NLZ13_27035) 1565..1755 + 191 Protein_1 hypothetical protein -
NLZ13_RS27035 (NLZ13_27040) 1828..2079 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLZ13_RS27040 (NLZ13_27045) 2076..2363 + 288 WP_000222760.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ13_RS27045 (NLZ13_27050) 2467..3057 + 591 WP_103556655.1 serine acetyltransferase -
NLZ13_RS27050 (NLZ13_27055) 3160..3825 + 666 WP_000536047.1 ProQ/FINO family protein -
NLZ13_RS27055 (NLZ13_27060) 3883..4197 + 315 WP_000633742.1 hypothetical protein -
NLZ13_RS27060 (NLZ13_27065) 4850..5347 - 498 WP_032297276.1 ATP-binding cassette domain-containing protein -
NLZ13_RS27065 (NLZ13_27070) 5321..6309 - 989 Protein_8 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..139970 139970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11105.15 Da        Isoelectric Point: 10.5832

>T250692 WP_000222760.1 NZ_CP100501:2076-2363 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT250692 WP_001132900.1 NZ_CP100501:1828-2079 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VJJ7

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References