250688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4868747..4869342 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag NLZ13_RS23730 Protein ID WP_000239577.1
Coordinates 4868747..4869097 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NLZ13_RS23735 Protein ID WP_001223208.1
Coordinates 4869091..4869342 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS23710 (4864196) 4864196..4865218 - 1023 WP_001313531.1 ABC transporter permease -
NLZ13_RS23715 (4865232) 4865232..4866734 - 1503 WP_000205807.1 sugar ABC transporter ATP-binding protein -
NLZ13_RS23720 (4866874) 4866874..4867830 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NLZ13_RS23725 (4868140) 4868140..4868670 + 531 WP_000055075.1 inorganic diphosphatase -
NLZ13_RS23730 (4868747) 4868747..4869097 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
NLZ13_RS23735 (4869091) 4869091..4869342 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NLZ13_RS23740 (4869554) 4869554..4869895 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NLZ13_RS23745 (4869898) 4869898..4873677 - 3780 WP_000060966.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T250688 WP_000239577.1 NZ_CP100500:c4869097-4868747 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT250688 WP_001223208.1 NZ_CP100500:c4869342-4869091 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References