250684

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4160899..4161517 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NLZ13_RS20580 Protein ID WP_001291435.1
Coordinates 4161299..4161517 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NLZ13_RS20575 Protein ID WP_000344800.1
Coordinates 4160899..4161273 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS20565 (4155988) 4155988..4157181 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NLZ13_RS20570 (4157204) 4157204..4160353 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NLZ13_RS20575 (4160899) 4160899..4161273 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NLZ13_RS20580 (4161299) 4161299..4161517 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NLZ13_RS20585 (4161689) 4161689..4162240 + 552 WP_000102564.1 maltose O-acetyltransferase -
NLZ13_RS20590 (4162356) 4162356..4162826 + 471 WP_000136192.1 YlaC family protein -
NLZ13_RS20595 (4162990) 4162990..4164540 + 1551 WP_001362407.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NLZ13_RS20600 (4164582) 4164582..4164935 - 354 WP_112037988.1 DUF1428 family protein -
NLZ13_RS20610 (4165314) 4165314..4165625 + 312 WP_000409914.1 MGMT family protein -
NLZ13_RS20615 (4165656) 4165656..4166228 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T250684 WP_001291435.1 NZ_CP100500:4161299-4161517 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT250684 WP_000344800.1 NZ_CP100500:4160899-4161273 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References