250683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3527373..3528111 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name yeeV Uniprot ID D8EF64
Locus tag NLZ13_RS17535 Protein ID WP_000847116.1
Coordinates 3527373..3527750 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NLZ13_RS17540 Protein ID WP_143360777.1
Coordinates 3527809..3528111 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS17505 (3524032) 3524032..3524736 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
NLZ13_RS17510 (3525021) 3525021..3525239 + 219 WP_001040187.1 translation initiation factor IF-1 -
NLZ13_RS17520 (3525732) 3525732..3526574 - 843 WP_077473180.1 DUF4942 domain-containing protein -
NLZ13_RS17525 (3526671) 3526671..3526868 - 198 WP_001349630.1 DUF957 domain-containing protein -
NLZ13_RS17530 (3526888) 3526888..3527376 - 489 WP_000777671.1 DUF5983 family protein -
NLZ13_RS17535 (3527373) 3527373..3527750 - 378 WP_000847116.1 TA system toxin CbtA family protein Toxin
NLZ13_RS17540 (3527809) 3527809..3528111 - 303 WP_143360777.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NLZ13_RS17545 (3528225) 3528225..3528869 - 645 WP_077473181.1 antitoxin of toxin-antitoxin stability system -
NLZ13_RS17550 (3528886) 3528886..3529107 - 222 WP_000692361.1 DUF987 domain-containing protein -
NLZ13_RS17555 (3529197) 3529197..3529673 - 477 WP_001186164.1 RadC family protein -
NLZ13_RS17560 (3529685) 3529685..3530158 - 474 WP_000860015.1 antirestriction protein -
NLZ13_RS17565 (3530263) 3530263..3531081 - 819 WP_072740735.1 DUF932 domain-containing protein -
NLZ13_RS17570 (3531182) 3531182..3531286 - 105 WP_106421522.1 DUF905 family protein -
NLZ13_RS17575 (3531486) 3531486..3531851 - 366 Protein_3455 hypothetical protein -
NLZ13_RS17580 (3531848) 3531848..3532039 - 192 Protein_3456 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14053.10 Da        Isoelectric Point: 7.8276

>T250683 WP_000847116.1 NZ_CP100500:c3527750-3527373 [Escherichia coli]
MKTFPDTHVRATSRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLISSIDILRARRATGLMTRSHYRMVNNITLGKHCEVKP

Download         Length: 378 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11003.64 Da        Isoelectric Point: 6.8395

>AT250683 WP_143360777.1 NZ_CP100500:c3528111-3527809 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGELSPRHQHTVTLYAKGLTCDA
DTLGSCGYVYIAIYPTPATP

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2EUN0

Antitoxin

Source ID Structure

References