250677

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2637511..2639099 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name hipA Uniprot ID U9YX51
Locus tag NLZ13_RS12930 Protein ID WP_001125448.1
Coordinates 2637511..2638833 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NLZ13_RS12935 Protein ID WP_023154249.1
Coordinates 2638833..2639099 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS12915 (2634903) 2634903..2635613 - 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -
NLZ13_RS12920 (2635974) 2635974..2636537 - 564 WP_000768279.1 type 1 fimbrial major subunit FimA -
NLZ13_RS12925 (2636971) 2636971..2637240 - 270 Protein_2535 AraC family transcriptional regulator -
NLZ13_RS12930 (2637511) 2637511..2638833 - 1323 WP_001125448.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NLZ13_RS12935 (2638833) 2638833..2639099 - 267 WP_023154249.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NLZ13_RS12940 (2639310) 2639310..2641453 - 2144 Protein_2538 autotransporter outer membrane beta-barrel domain-containing protein -
NLZ13_RS12945 (2641967) 2641967..2643559 - 1593 WP_000113112.1 autoinducer-2 kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / rhs/PAAR / espR1 / espR1 / fimA / sodB 2479620..2805307 325687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-400)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49363.02 Da        Isoelectric Point: 8.5823

>T250677 WP_001125448.1 NZ_CP100500:c2638833-2637511 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AVLDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10033.41 Da        Isoelectric Point: 6.2445

>AT250677 WP_023154249.1 NZ_CP100500:c2639099-2638833 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPES
TEKQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YX51

Antitoxin

Source ID Structure

References