250674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1625627..1626252 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NLZ13_RS07980 Protein ID WP_000911329.1
Coordinates 1625854..1626252 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NLZ13_RS07975 Protein ID WP_000450524.1
Coordinates 1625627..1625854 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS07950 (1621429) 1621429..1621899 - 471 WP_001068690.1 thioredoxin-dependent thiol peroxidase -
NLZ13_RS07955 (1621899) 1621899..1622471 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NLZ13_RS07960 (1622617) 1622617..1623495 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NLZ13_RS07965 (1623512) 1623512..1624546 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NLZ13_RS07970 (1624759) 1624759..1625472 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NLZ13_RS07975 (1625627) 1625627..1625854 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NLZ13_RS07980 (1625854) 1625854..1626252 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NLZ13_RS07985 (1626399) 1626399..1627262 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NLZ13_RS07990 (1627277) 1627277..1629292 + 2016 WP_089625697.1 tRNA cytosine(34) acetyltransferase TmcA -
NLZ13_RS07995 (1629366) 1629366..1630064 + 699 WP_000679812.1 esterase -
NLZ13_RS08000 (1630145) 1630145..1630345 - 201 WP_254539397.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - algU 1442080..1654414 212334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T250674 WP_000911329.1 NZ_CP100500:1625854-1626252 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT250674 WP_000450524.1 NZ_CP100500:1625627-1625854 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References