Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1131098..1131752 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NLZ13_RS05600 Protein ID WP_000244777.1
Coordinates 1131345..1131752 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NLZ13_RS05595 Protein ID WP_000354046.1
Coordinates 1131098..1131364 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS05575 (1127228) 1127228..1127539 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NLZ13_RS05580 (1127703) 1127703..1128362 + 660 WP_000250270.1 hemolysin III family protein -
NLZ13_RS05585 (1128449) 1128449..1129797 + 1349 WP_100245061.1 IS3-like element IS1397 family transposase -
NLZ13_RS05590 (1129875) 1129875..1130855 - 981 WP_000886100.1 tRNA-modifying protein YgfZ -
NLZ13_RS05595 (1131098) 1131098..1131364 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NLZ13_RS05600 (1131345) 1131345..1131752 + 408 WP_000244777.1 protein YgfX Toxin
NLZ13_RS05605 (1131792) 1131792..1132313 - 522 WP_001055874.1 flavodoxin FldB -
NLZ13_RS05610 (1132425) 1132425..1133321 + 897 WP_000806630.1 site-specific tyrosine recombinase XerD -
NLZ13_RS05615 (1133346) 1133346..1134056 + 711 WP_000715218.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ13_RS05620 (1134062) 1134062..1135795 + 1734 WP_000813236.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T250672 WP_000244777.1 NZ_CP100500:1131345-1131752 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT250672 WP_000354046.1 NZ_CP100500:1131098-1131364 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References