250670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 865035..865817 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M2EZB2
Locus tag NLZ13_RS04165 Protein ID WP_000854831.1
Coordinates 865035..865409 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NLZ13_RS04170 Protein ID WP_167823877.1
Coordinates 865455..865817 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS04140 (861133) 861133..862014 + 882 WP_000525605.1 integrase domain-containing protein -
NLZ13_RS04145 (862196) 862196..863463 - 1268 Protein_815 integrase arm-type DNA-binding domain-containing protein -
NLZ13_RS04150 (863758) 863758..864600 - 843 WP_112037804.1 DUF4942 domain-containing protein -
NLZ13_RS04155 (864685) 864685..864868 - 184 Protein_817 hypothetical protein -
NLZ13_RS04160 (864841) 864841..865035 - 195 Protein_818 DUF5983 family protein -
NLZ13_RS04165 (865035) 865035..865409 - 375 WP_000854831.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
NLZ13_RS04170 (865455) 865455..865817 - 363 WP_167823877.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NLZ13_RS04175 (865893) 865893..866114 - 222 WP_000692323.1 DUF987 domain-containing protein -
NLZ13_RS04180 (866177) 866177..866653 - 477 WP_123001450.1 RadC family protein -
NLZ13_RS04185 (866669) 866669..867154 - 486 WP_112037803.1 antirestriction protein -
NLZ13_RS04190 (867246) 867246..868064 - 819 WP_001234392.1 DUF932 domain-containing protein -
NLZ13_RS04195 (868155) 868155..868388 - 234 WP_112037802.1 DUF905 family protein -
NLZ13_RS04200 (868394) 868394..869071 - 678 WP_029490458.1 hypothetical protein -
NLZ13_RS04205 (869190) 869190..870074 - 885 WP_254539366.1 YfjP family GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14051.18 Da        Isoelectric Point: 8.4983

>T250670 WP_000854831.1 NZ_CP100500:c865409-865035 [Escherichia coli]
MKTLPVLPKQAASSRPSPLEIWQILLTRLLDQHYGLTLHDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13168.91 Da        Isoelectric Point: 5.4549

>AT250670 WP_167823877.1 NZ_CP100500:c865817-865455 [Escherichia coli]
VSDTLPDDNHDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSGELSPR
HQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPAVPATTA

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2EZB2

Antitoxin

Source ID Structure

References