250667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 367517..368317 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name ataT Uniprot ID U9Y257
Locus tag NLZ13_RS01730 Protein ID WP_000342447.1
Coordinates 367790..368317 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID U9Y285
Locus tag NLZ13_RS01725 Protein ID WP_001277109.1
Coordinates 367517..367783 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS01705 (363175) 363175..363843 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
NLZ13_RS01710 (363836) 363836..364894 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
NLZ13_RS01715 (365139) 365139..365993 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NLZ13_RS01720 (366264) 366264..367367 + 1104 WP_112037866.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NLZ13_RS01725 (367517) 367517..367783 + 267 WP_001277109.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NLZ13_RS01730 (367790) 367790..368317 + 528 WP_000342447.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NLZ13_RS01735 (368314) 368314..368697 - 384 WP_000778769.1 aspartate 1-decarboxylase autocleavage activator PanM -
NLZ13_RS01740 (369121) 369121..370230 + 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NLZ13_RS01745 (370278) 370278..371204 + 927 WP_112037865.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NLZ13_RS01750 (371201) 371201..372478 + 1278 WP_000803778.1 branched chain amino acid ABC transporter permease LivM -
NLZ13_RS01755 (372475) 372475..373242 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.63 Da        Isoelectric Point: 7.0284

>T250667 WP_000342447.1 NZ_CP100500:367790-368317 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDHSIQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.37 Da        Isoelectric Point: 10.0863

>AT250667 WP_001277109.1 NZ_CP100500:367517-367783 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AVKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LUM2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LUN0

References