250666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 325077..325708 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag NLZ13_RS01480 Protein ID WP_001259385.1
Coordinates 325077..325352 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NLZ13_RS01485 Protein ID WP_000593555.1
Coordinates 325349..325708 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS01465 (320081) 320081..321148 + 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -
NLZ13_RS01470 (321145) 321145..323880 + 2736 WP_000149185.1 ribosome-associated ATPase/putative transporter RbbA -
NLZ13_RS01475 (323880) 323880..325004 + 1125 WP_001314210.1 ABC transporter permease -
NLZ13_RS01480 (325077) 325077..325352 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
NLZ13_RS01485 (325349) 325349..325708 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NLZ13_RS01490 (325758) 325758..326618 - 861 WP_001131795.1 class II aldolase -
NLZ13_RS01495 (326650) 326650..326919 - 270 WP_000933060.1 HPr family phosphocarrier protein -
NLZ13_RS01500 (326909) 326909..328417 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
NLZ13_RS01505 (328410) 328410..329768 - 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
NLZ13_RS01510 (329845) 329845..330126 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
NLZ13_RS01515 (330123) 330123..330596 - 474 WP_001161550.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T250666 WP_001259385.1 NZ_CP100500:325077-325352 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT250666 WP_000593555.1 NZ_CP100500:325349-325708 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References