250665

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49621..50453 Replicon chromosome
Accession NZ_CP100500
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NLZ13_RS00255 Protein ID WP_112037996.1
Coordinates 49621..49995 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag NLZ13_RS00260 Protein ID WP_001280951.1
Coordinates 50085..50453 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS00225 (44987) 44987..45910 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
NLZ13_RS00230 (46021) 46021..47205 - 1185 WP_001172864.1 sugar efflux transporter -
NLZ13_RS00235 (47602) 47602..47763 - 162 Protein_46 virulence RhuM family protein -
NLZ13_RS00240 (47997) 47997..48842 - 846 WP_001406222.1 DUF4942 domain-containing protein -
NLZ13_RS00245 (48927) 48927..49124 - 198 WP_000839243.1 DUF957 domain-containing protein -
NLZ13_RS00250 (49136) 49136..49624 - 489 WP_112037997.1 DUF5983 family protein -
NLZ13_RS00255 (49621) 49621..49995 - 375 WP_112037996.1 TA system toxin CbtA family protein Toxin
NLZ13_RS00260 (50085) 50085..50453 - 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NLZ13_RS00265 (50616) 50616..50837 - 222 WP_001405861.1 DUF987 domain-containing protein -
NLZ13_RS00270 (50906) 50906..51382 - 477 WP_001186724.1 RadC family protein -
NLZ13_RS00275 (51398) 51398..51883 - 486 WP_001469549.1 antirestriction protein -
NLZ13_RS00280 (51979) 51979..52797 - 819 WP_112037995.1 DUF932 domain-containing protein -
NLZ13_RS00285 (52897) 52897..53130 - 234 WP_094158925.1 DUF905 family protein -
NLZ13_RS00290 (53209) 53209..53664 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14004.02 Da        Isoelectric Point: 8.7453

>T250665 WP_112037996.1 NZ_CP100500:c49995-49621 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTNQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT250665 WP_001280951.1 NZ_CP100500:c50453-50085 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References