250663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 20305..21056 Replicon plasmid pLH71-A
Accession NZ_CP100498
Organism Klebsiella michiganensis strain LH71

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NLZ14_RS27655 Protein ID WP_032694614.1
Coordinates 20574..21056 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag NLZ14_RS27650 Protein ID WP_004902250.1
Coordinates 20305..20583 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ14_RS27620 (NLZ14_27620) 15378..16667 - 1290 WP_032694618.1 arsenic transporter -
NLZ14_RS27625 (NLZ14_27625) 16714..18465 - 1752 WP_032694617.1 arsenical pump-driving ATPase -
NLZ14_RS27630 (NLZ14_27630) 18482..18844 - 363 WP_254540129.1 arsenite efflux transporter metallochaperone ArsD -
NLZ14_RS27635 (NLZ14_27635) 18892..19245 - 354 WP_025376942.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
NLZ14_RS27640 (NLZ14_27640) 19549..19890 + 342 WP_254540118.1 hypothetical protein -
NLZ14_RS27645 (NLZ14_27645) 19961..20183 + 223 Protein_19 hypothetical protein -
NLZ14_RS27650 (NLZ14_27650) 20305..20583 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
NLZ14_RS27655 (NLZ14_27655) 20574..21056 + 483 WP_032694614.1 GNAT family N-acetyltransferase Toxin
NLZ14_RS27660 (NLZ14_27660) 21412..21804 - 393 WP_223239433.1 hypothetical protein -
NLZ14_RS27665 (NLZ14_27665) 22035..22340 + 306 WP_254540119.1 hypothetical protein -
NLZ14_RS27675 (NLZ14_27675) 23513..24094 + 582 Protein_25 EcsC family protein -
NLZ14_RS27680 (NLZ14_27680) 24125..25858 + 1734 WP_088168634.1 DUF262 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..125674 125674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-146)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17678.45 Da        Isoelectric Point: 8.9130

>T250663 WP_032694614.1 NZ_CP100498:20574-21056 [Klebsiella michiganensis]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENSNRVIGYYCLSSGSVHRNTVPGAYRRNAP
EVIPVIVLGRLAIDQAWSGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT250663 WP_004902250.1 NZ_CP100498:20305-20583 [Klebsiella michiganensis]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References