Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4680653..4681472 Replicon chromosome
Accession NZ_CP100497
Organism Klebsiella michiganensis strain LH71

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag NLZ14_RS22005 Protein ID WP_004110819.1
Coordinates 4681215..4681472 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A7H4N6T4
Locus tag NLZ14_RS22000 Protein ID WP_064358621.1
Coordinates 4680653..4681204 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ14_RS21980 (NLZ14_21980) 4676023..4677420 + 1398 WP_014228060.1 MFS transporter -
NLZ14_RS21985 (NLZ14_21985) 4677542..4678882 + 1341 WP_032748099.1 carbohydrate porin -
NLZ14_RS21990 (NLZ14_21990) 4679007..4679753 - 747 WP_224376009.1 class I SAM-dependent methyltransferase -
NLZ14_RS21995 (NLZ14_21995) 4680177..4680539 - 363 Protein_4330 class I SAM-dependent methyltransferase -
NLZ14_RS22000 (NLZ14_22000) 4680653..4681204 - 552 WP_064358621.1 N-acetyltransferase Antitoxin
NLZ14_RS22005 (NLZ14_22005) 4681215..4681472 - 258 WP_004110819.1 YjhX family toxin Toxin
NLZ14_RS22010 (NLZ14_22010) 4682148..4683332 + 1185 WP_014228054.1 mannonate dehydratase -
NLZ14_RS22015 (NLZ14_22015) 4683406..4684881 + 1476 WP_014228053.1 fructuronate reductase -
NLZ14_RS22020 (NLZ14_22020) 4685020..4685796 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(23-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T250661 WP_004110819.1 NZ_CP100497:c4681472-4681215 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19956.80 Da        Isoelectric Point: 6.2120

>AT250661 WP_064358621.1 NZ_CP100497:c4681204-4680653 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILNVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRLGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWCE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7H4N6T4

References