25066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3883240..3884992 Replicon chromosome
Accession NC_014931
Organism Variovorax paradoxus EPS

Toxin (Protein)


Gene name doc Uniprot ID E6UYF3
Locus tag VARPA_RS17950 Protein ID WP_013542004.1
Coordinates 3884120..3884992 (-) Length 291 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID E6UYF2
Locus tag VARPA_RS17945 Protein ID WP_013542003.1
Coordinates 3883240..3884079 (-) Length 280 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VARPA_RS17925 3878377..3879852 - 1476 WP_013541999.1 aldehyde dehydrogenase -
VARPA_RS17930 3879870..3880658 - 789 WP_200861488.1 aspartate dehydrogenase -
VARPA_RS17935 3880688..3882388 - 1701 WP_013542001.1 thiamine pyrophosphate-binding protein -
VARPA_RS17940 3882381..3883217 - 837 WP_080559449.1 SDR family oxidoreductase -
VARPA_RS17945 3883240..3884079 - 840 WP_013542003.1 IclR family transcriptional regulator Antitoxin
VARPA_RS17950 3884120..3884992 - 873 WP_013542004.1 alpha/beta hydrolase Toxin
VARPA_RS17955 3885000..3885548 - 549 WP_013542005.1 cupin domain-containing protein -
VARPA_RS17960 3885582..3886397 - 816 WP_013542006.1 SDR family oxidoreductase -
VARPA_RS17965 3886405..3887391 - 987 WP_013542007.1 tripartite tricarboxylate transporter substrate binding protein -
VARPA_RS17970 3887567..3888826 - 1260 WP_013542008.1 D-amino acid dehydrogenase -
VARPA_RS17975 3888878..3889894 - 1017 WP_013542009.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(48-282)

Antitoxin

Transcription regulator IclR, C-terminal

(141-260)


Sequences

Toxin        


Download         Length: 291 a.a.        Molecular weight: 29779.19 Da        Isoelectric Point: 6.4853

>T25066 WP_013542004.1 NC_014931:c3884992-3884120 [Variovorax paradoxus EPS]
MSDAMVIDALTLPASELALLDARFPARDVPVGGGAVVSVREHGAGPALVCLHGIGSGAASWLNVALLLAPQARVIAWDAP
GYGQSTPLAPAAPSAADYAERLHALLDALDVQSCVLVGHSLGALTAASAARKDSAIASRIRRLVLISPAAGYGAPSRAEA
RARVRAERLATLDELGIAGMASKRAGRLVSDGASELARQWVRWNMARLNDGGYRQAVELLCHGDLLADLPPAMPVRVACG
TLDVVTTPQACAEVARGCGVTLEAIDGAGHASYVERPEAVAALLREALAA

Download         Length: 873 bp

>T25066 NC_014931:c3884992-3884120 [Variovorax paradoxus EPS]
ATGAGCGACGCGATGGTCATCGATGCATTGACGCTGCCCGCTTCCGAGCTGGCGCTGCTCGACGCCCGCTTTCCCGCACG
CGACGTGCCGGTCGGCGGTGGCGCGGTGGTGTCGGTGCGCGAGCACGGCGCGGGTCCGGCCCTCGTGTGCCTGCACGGCA
TCGGCTCGGGCGCGGCCTCGTGGCTCAACGTCGCCTTGCTGCTGGCTCCGCAGGCCCGCGTGATCGCATGGGATGCGCCG
GGCTACGGCCAATCCACGCCGCTCGCGCCTGCCGCACCATCTGCAGCGGACTACGCGGAACGCCTGCATGCCTTGCTCGA
TGCGCTCGATGTCCAGTCTTGCGTGCTCGTCGGCCACTCGCTCGGCGCACTCACCGCGGCATCGGCCGCGCGGAAAGATT
CAGCAATTGCCTCGCGCATCCGCCGCCTCGTGCTCATCAGCCCGGCCGCCGGCTACGGCGCACCGTCGCGCGCCGAAGCC
CGCGCCAGGGTGCGCGCCGAACGCCTCGCCACGCTCGACGAACTCGGCATCGCCGGCATGGCGTCGAAACGCGCGGGCCG
CCTCGTTTCCGACGGCGCGAGCGAACTCGCTCGCCAGTGGGTGCGCTGGAATATGGCCCGCCTGAACGACGGCGGCTACC
GCCAGGCCGTTGAGCTGCTGTGCCACGGCGACCTGCTGGCCGACCTGCCGCCCGCCATGCCGGTGCGCGTGGCCTGTGGC
ACGCTCGATGTCGTCACCACGCCCCAAGCCTGCGCCGAAGTCGCGCGCGGCTGCGGGGTGACGCTCGAAGCCATCGACGG
TGCCGGGCACGCCAGCTACGTGGAGCGGCCCGAGGCCGTCGCCGCGCTGCTGCGCGAGGCACTCGCCGCCTGA

Antitoxin


Download         Length: 280 a.a.        Molecular weight: 30863.20 Da        Isoelectric Point: 5.7759

>AT25066 WP_013542003.1 NC_014931:c3884079-3883240 [Variovorax paradoxus EPS]
MTTNDNSEAMEEGADRYNVPALERGLRVLCEFSRENRTLSAPELARRFDLPRSTVFRLLTTLENMGFLERAEGGRDYRLG
LAVLRLGFEYLASLELTQLGTPLLNRLCDELRTPCNLVVRDGRSIVYVAKVAPPTPFASSVTVGTRLPAHATVLGRVLLE
DLTLPQLRALYPEDKLETFSPSTPKTVNELFDMVQADRTRGYVLGEGFFESNISSIAAPVRDHSGHIVAALGATITSGHI
EENRMDEMVLRVRSTAEEISGLLNYSPARSNKVVPLRSA

Download         Length: 840 bp

>AT25066 NC_014931:c3884079-3883240 [Variovorax paradoxus EPS]
ATGACCACCAACGACAACAGCGAAGCGATGGAAGAGGGCGCCGACCGCTACAACGTGCCTGCGCTGGAGCGCGGCCTGCG
CGTGCTGTGCGAGTTCAGCCGCGAGAACCGCACGCTCTCCGCGCCCGAGCTGGCGCGCCGCTTCGACCTGCCGCGTTCGA
CCGTGTTCCGCCTGCTCACCACGCTGGAGAACATGGGCTTCCTGGAGCGCGCCGAGGGCGGCCGCGACTACCGCCTAGGC
CTCGCGGTGCTGCGCCTGGGCTTCGAATACCTGGCCTCGCTCGAACTCACGCAACTGGGCACGCCGCTGCTCAACCGCCT
GTGCGATGAACTGCGCACGCCTTGCAACCTGGTGGTGCGCGACGGCCGCTCGATCGTCTACGTCGCCAAGGTCGCACCGC
CGACGCCCTTCGCCAGTTCGGTCACCGTCGGCACGCGCCTGCCGGCCCACGCCACGGTCCTCGGCCGCGTGCTGCTGGAA
GACCTCACGCTGCCGCAGCTTCGCGCGCTCTACCCCGAAGACAAGCTGGAGACCTTCTCGCCGAGCACGCCCAAGACGGT
GAACGAACTCTTCGACATGGTGCAGGCCGACCGCACGCGCGGCTATGTGCTGGGCGAAGGTTTCTTCGAGTCGAACATCT
CCAGCATCGCCGCGCCGGTGCGCGACCACAGTGGCCACATCGTTGCTGCCCTGGGCGCGACCATCACCTCGGGCCACATC
GAAGAGAACCGCATGGACGAAATGGTGCTGCGGGTGCGCAGTACCGCGGAGGAGATCTCGGGCCTCTTGAACTACTCGCC
TGCGCGCAGCAACAAGGTGGTGCCGCTTCGCAGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E6UYF3

Antitoxin

Source ID Structure
AlphaFold DB E6UYF2

References