Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 897121..897778 Replicon chromosome
Accession NZ_CP100497
Organism Klebsiella michiganensis strain LH71

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag NLZ14_RS04325 Protein ID WP_004854060.1
Coordinates 897368..897778 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag NLZ14_RS04320 Protein ID WP_004124953.1
Coordinates 897121..897387 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ14_RS04305 (NLZ14_04305) 892355..892780 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
NLZ14_RS04310 (NLZ14_04310) 892901..895699 - 2799 WP_014226794.1 transcriptional regulator DagR -
NLZ14_RS04315 (NLZ14_04315) 895893..896876 - 984 WP_254539816.1 tRNA-modifying protein YgfZ -
NLZ14_RS04320 (NLZ14_04320) 897121..897387 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
NLZ14_RS04325 (NLZ14_04325) 897368..897778 + 411 WP_004854060.1 protein YgfX Toxin
NLZ14_RS04330 (NLZ14_04330) 897787..898308 - 522 WP_014226792.1 flavodoxin FldB -
NLZ14_RS04335 (NLZ14_04335) 898430..899326 + 897 WP_046876662.1 site-specific tyrosine recombinase XerD -
NLZ14_RS04340 (NLZ14_04340) 899349..900062 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ14_RS04345 (NLZ14_04345) 900068..901801 + 1734 WP_032751182.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T250654 WP_004854060.1 NZ_CP100497:897368-897778 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT250654 WP_004124953.1 NZ_CP100497:897121-897387 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References