Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 663575..664167 Replicon chromosome
Accession NZ_CP100497
Organism Klebsiella michiganensis strain LH71

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag NLZ14_RS03225 Protein ID WP_004105955.1
Coordinates 663793..664167 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag NLZ14_RS03220 Protein ID WP_004105957.1
Coordinates 663575..663796 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ14_RS03200 (NLZ14_03200) 659132..659686 + 555 WP_254539797.1 YgjV family protein -
NLZ14_RS03205 (NLZ14_03205) 659705..660952 - 1248 WP_004105963.1 serine/threonine transporter SstT -
NLZ14_RS03210 (NLZ14_03210) 661207..662175 - 969 WP_181251403.1 TerC family protein -
NLZ14_RS03215 (NLZ14_03215) 662426..663415 - 990 WP_049071572.1 Gfo/Idh/MocA family oxidoreductase -
NLZ14_RS03220 (NLZ14_03220) 663575..663796 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NLZ14_RS03225 (NLZ14_03225) 663793..664167 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NLZ14_RS03230 (NLZ14_03230) 664147..664650 - 504 WP_254539798.1 M48 family metallopeptidase -
NLZ14_RS03235 (NLZ14_03235) 664729..666372 - 1644 WP_254539799.1 glycoside hydrolase family 43 protein -
NLZ14_RS03240 (NLZ14_03240) 666501..667367 - 867 WP_038423701.1 AraC family transcriptional regulator -
NLZ14_RS03245 (NLZ14_03245) 667475..668818 + 1344 WP_046878299.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T250653 WP_004105955.1 NZ_CP100497:663793-664167 [Klebsiella michiganensis]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT250653 WP_004105957.1 NZ_CP100497:663575-663796 [Klebsiella michiganensis]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References