Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid pLH85-a-B
Accession NZ_CP100488
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag NLZ16_RS24960 Protein ID WP_001384452.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag NLZ16_RS24955 Protein ID WP_032181987.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS24950 (46) 46..1077 + 1032 WP_044706701.1 plasmid replication initiator RepA -
NLZ16_RS24955 (1986) 1986..2255 + 270 WP_032181987.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NLZ16_RS24960 (2255) 2255..2533 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
NLZ16_RS24965 (2573) 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
NLZ16_RS24970 (3538) 3538..4011 + 474 WP_001334658.1 hypothetical protein -
NLZ16_RS24975 (4488) 4488..4754 - 267 WP_000627831.1 hypothetical protein -
NLZ16_RS24980 (4754) 4754..5248 - 495 WP_001350009.1 hypothetical protein -
NLZ16_RS24985 (5304) 5304..5906 - 603 WP_045133169.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..87908 87908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T250634 WP_001384452.1 NZ_CP100488:2255-2533 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10177.47 Da        Isoelectric Point: 6.7251

>AT250634 WP_032181987.1 NZ_CP100488:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure

References