Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4396464..4397059 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag NLZ16_RS20880 Protein ID WP_019842229.1
Coordinates 4396464..4396814 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NLZ16_RS20885 Protein ID WP_001223213.1
Coordinates 4396808..4397059 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS20860 (4391794) 4391794..4392816 - 1023 WP_001550507.1 ABC transporter permease -
NLZ16_RS20865 (4392830) 4392830..4394332 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
NLZ16_RS20870 (4394464) 4394464..4395420 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NLZ16_RS20875 (4395730) 4395730..4396260 + 531 WP_000055075.1 inorganic diphosphatase -
NLZ16_RS20880 (4396464) 4396464..4396814 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
NLZ16_RS20885 (4396808) 4396808..4397059 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NLZ16_RS20890 (4397271) 4397271..4397612 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
NLZ16_RS20895 (4397615) 4397615..4401394 - 3780 WP_001596432.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T250629 WP_019842229.1 NZ_CP100486:c4396814-4396464 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT250629 WP_001223213.1 NZ_CP100486:c4397059-4396808 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References