Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4384802..4385324 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NLZ16_RS20820 Protein ID WP_001105433.1
Coordinates 4384802..4385092 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NLZ16_RS20825 Protein ID WP_000212715.1
Coordinates 4385082..4385324 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS20805 (4379970) 4379970..4381625 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
NLZ16_RS20810 (4382019) 4382019..4384157 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
NLZ16_RS20815 (4384337) 4384337..4384801 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NLZ16_RS20820 (4384802) 4384802..4385092 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ16_RS20825 (4385082) 4385082..4385324 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NLZ16_RS20830 (4385516) 4385516..4385902 - 387 WP_001232246.1 cytochrome b562 -
NLZ16_RS20835 (4386085) 4386085..4387437 - 1353 WP_001162173.1 metalloprotease PmbA -
NLZ16_RS20840 (4387531) 4387531..4388082 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
NLZ16_RS20845 (4388232) 4388232..4389605 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T250628 WP_001105433.1 NZ_CP100486:c4385092-4384802 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT250628 WP_000212715.1 NZ_CP100486:c4385324-4385082 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References