Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3708412..3709030 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NLZ16_RS17700 Protein ID WP_001291435.1
Coordinates 3708812..3709030 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NLZ16_RS17695 Protein ID WP_000344800.1
Coordinates 3708412..3708786 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS17685 (3703501) 3703501..3704694 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NLZ16_RS17690 (3704717) 3704717..3707866 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NLZ16_RS17695 (3708412) 3708412..3708786 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NLZ16_RS17700 (3708812) 3708812..3709030 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NLZ16_RS17705 (3709202) 3709202..3709753 + 552 WP_000102564.1 maltose O-acetyltransferase -
NLZ16_RS17710 (3709869) 3709869..3710339 + 471 WP_000136192.1 YlaC family protein -
NLZ16_RS17715 (3710503) 3710503..3712053 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NLZ16_RS17720 (3712095) 3712095..3712448 - 354 WP_001550741.1 DUF1428 family protein -
NLZ16_RS17730 (3712827) 3712827..3713138 + 312 WP_000409911.1 MGMT family protein -
NLZ16_RS17735 (3713169) 3713169..3713741 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T250625 WP_001291435.1 NZ_CP100486:3708812-3709030 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT250625 WP_000344800.1 NZ_CP100486:3708412-3708786 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References