Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3307223..3307928 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NLZ16_RS15935 Protein ID WP_000539521.1
Coordinates 3307223..3307609 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NLZ16_RS15940 Protein ID WP_001280945.1
Coordinates 3307599..3307928 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS15915 (3303227) 3303227..3303853 + 627 WP_001295292.1 glutathione S-transferase GstB -
NLZ16_RS15920 (3303850) 3303850..3304965 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
NLZ16_RS15925 (3305076) 3305076..3305459 - 384 WP_000497137.1 biofilm formation regulator BssR -
NLZ16_RS15930 (3305672) 3305672..3306997 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NLZ16_RS15935 (3307223) 3307223..3307609 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ16_RS15940 (3307599) 3307599..3307928 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NLZ16_RS15945 (3307998) 3307998..3309326 - 1329 WP_001550887.1 GGDEF domain-containing protein -
NLZ16_RS15950 (3309334) 3309334..3311682 - 2349 WP_001550886.1 EAL domain-containing protein -
NLZ16_RS15955 (3311860) 3311860..3312771 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T250624 WP_000539521.1 NZ_CP100486:3307223-3307609 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT250624 WP_001280945.1 NZ_CP100486:3307599-3307928 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References