Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2586332..2586970 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NLZ16_RS12440 Protein ID WP_000813795.1
Coordinates 2586332..2586508 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NLZ16_RS12445 Protein ID WP_076797675.1
Coordinates 2586554..2586970 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS12420 (2581954) 2581954..2583126 - 1173 WP_001551088.1 BenE family transporter YdcO -
NLZ16_RS12425 (2583218) 2583218..2583754 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NLZ16_RS12430 (2583827) 2583827..2585788 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NLZ16_RS12435 (2585880) 2585880..2586110 - 231 WP_023910283.1 YncJ family protein -
NLZ16_RS12440 (2586332) 2586332..2586508 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NLZ16_RS12445 (2586554) 2586554..2586970 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NLZ16_RS12450 (2587049) 2587049..2588455 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NLZ16_RS12455 (2588700) 2588700..2589845 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
NLZ16_RS12460 (2589863) 2589863..2590876 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NLZ16_RS12465 (2590877) 2590877..2591818 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T250621 WP_000813795.1 NZ_CP100486:2586332-2586508 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT250621 WP_076797675.1 NZ_CP100486:2586554-2586970 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References