Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4602654..4603189 Replicon chromosome
Accession NC_014923
Organism Mesorhizobium ciceri biovar biserrulae WSM1271

Toxin (Protein)


Gene name relE Uniprot ID E8THD9
Locus tag MESCI_RS22440 Protein ID WP_013532246.1
Coordinates 4602654..4602929 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E8THE0
Locus tag MESCI_RS22445 Protein ID WP_013532247.1
Coordinates 4602929..4603189 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MESCI_RS22415 4598673..4599584 - 912 WP_013532241.1 ABC transporter substrate-binding protein -
MESCI_RS22420 4599789..4600361 + 573 WP_013532242.1 NAD(P)H-dependent oxidoreductase -
MESCI_RS22425 4600370..4601584 - 1215 WP_013532243.1 MFS transporter -
MESCI_RS22430 4601581..4602081 - 501 WP_013532244.1 transcription antitermination factor NusB -
MESCI_RS22435 4602078..4602572 - 495 WP_013532245.1 6,7-dimethyl-8-ribityllumazine synthase -
MESCI_RS22440 4602654..4602929 - 276 WP_013532246.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MESCI_RS22445 4602929..4603189 - 261 WP_013532247.1 ribbon-helix-helix domain-containing protein Antitoxin
MESCI_RS22450 4603253..4603870 - 618 WP_013532248.1 riboflavin synthase -
MESCI_RS22455 4603883..4604998 - 1116 WP_013532249.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
MESCI_RS22460 4605001..4605480 - 480 WP_013532250.1 transcriptional regulator NrdR -
MESCI_RS22465 4605638..4606258 - 621 WP_174299090.1 hypothetical protein -
MESCI_RS22470 4606338..4607651 - 1314 WP_013532252.1 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10616.20 Da        Isoelectric Point: 8.5620

>T25062 WP_013532246.1 NC_014923:c4602929-4602654 [Mesorhizobium ciceri biovar biserrulae WSM1271]
MELKWTNKALSDLVRLHDFLVLANGPAAARAVQSLTAAPARLVEYPRIGERLEEFEPREVRRILVGSYEIRYEIQNTTIS
VLRLWHTREDR

Download         Length: 276 bp

>T25062 NC_014923:c4602929-4602654 [Mesorhizobium ciceri biovar biserrulae WSM1271]
ATGGAGTTGAAATGGACCAACAAGGCTTTGTCCGACTTGGTCCGGCTACATGATTTTCTCGTGCTAGCAAATGGCCCGGC
GGCCGCACGTGCCGTGCAGTCGCTTACTGCCGCGCCGGCACGGTTGGTCGAATATCCGCGCATCGGTGAGAGACTGGAAG
AGTTCGAACCACGAGAAGTGCGTCGCATTTTGGTAGGCAGCTACGAAATTCGTTACGAGATACAGAACACGACAATTTCT
GTGTTGCGCCTGTGGCATACGCGAGAGGATCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9646.11 Da        Isoelectric Point: 5.6994

>AT25062 WP_013532247.1 NC_014923:c4603189-4602929 [Mesorhizobium ciceri biovar biserrulae WSM1271]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERRRLTLEAMADVDAGRVIDHQAVQAWAESLGTDK
PLPVPR

Download         Length: 261 bp

>AT25062 NC_014923:c4603189-4602929 [Mesorhizobium ciceri biovar biserrulae WSM1271]
ATGGATACAAAAGTAATCACCGCTCACGTTCCGCTGCCGCTGGCTGAAAAGGTAGATCAACTGGCTGCCCGCCTTGAGCG
CCCACGCGGCTGGATCGTCAAACAAGCTCTTTCCGCGTGGGTGGATTTGGAGGAGGAGCGCCGACGGCTCACGCTTGAAG
CAATGGCCGATGTCGACGCAGGACGGGTCATCGATCACCAGGCCGTGCAGGCGTGGGCTGAGAGTCTTGGTACCGACAAG
CCACTGCCGGTGCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S2Q9F8

Antitoxin

Source ID Structure
AlphaFold DB A0A436MZK2

References