Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1058570..1059224 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NLZ16_RS05110 Protein ID WP_000244781.1
Coordinates 1058817..1059224 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag NLZ16_RS05105 Protein ID WP_001564007.1
Coordinates 1058570..1058836 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS05085 (1054658) 1054658..1056091 - 1434 WP_001513393.1 6-phospho-beta-glucosidase BglA -
NLZ16_RS05090 (1056136) 1056136..1056447 + 312 WP_001182951.1 N(4)-acetylcytidine aminohydrolase -
NLZ16_RS05095 (1056611) 1056611..1057270 + 660 WP_000250274.1 hemolysin III family protein -
NLZ16_RS05100 (1057347) 1057347..1058327 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
NLZ16_RS05105 (1058570) 1058570..1058836 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
NLZ16_RS05110 (1058817) 1058817..1059224 + 408 WP_000244781.1 protein YgfX Toxin
NLZ16_RS05115 (1059264) 1059264..1059785 - 522 WP_001055874.1 flavodoxin FldB -
NLZ16_RS05120 (1059897) 1059897..1060793 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NLZ16_RS05125 (1060818) 1060818..1061528 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ16_RS05130 (1061534) 1061534..1063267 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T250613 WP_000244781.1 NZ_CP100486:1058817-1059224 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT250613 WP_001564007.1 NZ_CP100486:1058570-1058836 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References