Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 794898..795655 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag NLZ16_RS03815 Protein ID WP_001094452.1
Coordinates 795281..795655 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7WZL4
Locus tag NLZ16_RS03810 Protein ID WP_071788590.1
Coordinates 794898..795191 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS03790 (792572) 792572..793390 + 819 WP_001564116.1 DUF932 domain-containing protein -
NLZ16_RS03795 (793482) 793482..793967 + 486 WP_000206669.1 antirestriction protein -
NLZ16_RS03800 (793983) 793983..794459 + 477 WP_001186706.1 RadC family protein -
NLZ16_RS03805 (794522) 794522..794743 + 222 WP_000692345.1 DUF987 domain-containing protein -
NLZ16_RS03810 (794898) 794898..795191 + 294 WP_071788590.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NLZ16_RS03815 (795281) 795281..795655 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
NLZ16_RS03820 (795652) 795652..796143 + 492 WP_000976868.1 DUF5983 family protein -
NLZ16_RS03825 (796155) 796155..796352 + 198 WP_000772035.1 DUF957 domain-containing protein -
NLZ16_RS03830 (796449) 796449..797294 + 846 WP_001290254.1 DUF4942 domain-containing protein -
NLZ16_RS03840 (797593) 797593..798099 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
NLZ16_RS03845 (798178) 798178..800019 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(1-92)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T250611 WP_001094452.1 NZ_CP100486:795281-795655 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10804.40 Da        Isoelectric Point: 8.2692

>AT250611 WP_071788590.1 NZ_CP100486:794898-795191 [Escherichia coli]
VTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKADTLG
SCGYVYLAVYPTSETKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure

References