Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 195107..195719 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NLZ16_RS00865 Protein ID WP_000833473.1
Coordinates 195107..195292 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag NLZ16_RS00870 Protein ID WP_000499744.1
Coordinates 195309..195719 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS00855 (191948) 191948..193099 + 1152 WP_000741501.1 L-threonine dehydrogenase -
NLZ16_RS00860 (193300) 193300..194838 + 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
NLZ16_RS00865 (195107) 195107..195292 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NLZ16_RS00870 (195309) 195309..195719 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NLZ16_RS00875 (195791) 195791..197755 - 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
NLZ16_RS00880 (197766) 197766..199166 - 1401 WP_000204811.1 MFS transporter -
NLZ16_RS00885 (199392) 199392..200207 + 816 WP_000891823.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T250609 WP_000833473.1 NZ_CP100486:195107-195292 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT250609 WP_000499744.1 NZ_CP100486:195309-195719 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References