Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 72581..73413 Replicon chromosome
Accession NZ_CP100486
Organism Escherichia coli strain LH85-a

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag NLZ16_RS00310 Protein ID WP_000854753.1
Coordinates 72581..72955 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag NLZ16_RS00315 Protein ID WP_001280951.1
Coordinates 73045..73413 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ16_RS00280 (67948) 67948..68871 - 924 WP_000535949.1 carboxylate/amino acid/amine transporter -
NLZ16_RS00285 (68982) 68982..70166 - 1185 WP_001172876.1 sugar efflux transporter -
NLZ16_RS00290 (70571) 70571..70776 - 206 Protein_57 virulence RhuM family protein -
NLZ16_RS00295 (70957) 70957..71802 - 846 WP_001406222.1 DUF4942 domain-containing protein -
NLZ16_RS00300 (71887) 71887..72084 - 198 WP_000839243.1 DUF957 domain-containing protein -
NLZ16_RS00305 (72096) 72096..72584 - 489 WP_001549830.1 DUF5983 family protein -
NLZ16_RS00310 (72581) 72581..72955 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
NLZ16_RS00315 (73045) 73045..73413 - 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NLZ16_RS00320 (73576) 73576..73797 - 222 WP_001405861.1 DUF987 domain-containing protein -
NLZ16_RS00325 (73866) 73866..74342 - 477 WP_001186724.1 RadC family protein -
NLZ16_RS00330 (74358) 74358..74843 - 486 WP_001469549.1 antirestriction protein -
NLZ16_RS00335 (74898) 74898..75716 - 819 WP_001234620.1 DUF932 domain-containing protein -
NLZ16_RS00340 (75816) 75816..76049 - 234 WP_001119729.1 DUF905 family protein -
NLZ16_RS00345 (76128) 76128..76583 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T250608 WP_000854753.1 NZ_CP100486:c72955-72581 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT250608 WP_001280951.1 NZ_CP100486:c73413-73045 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References