250607

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5850877..5851487 Replicon chromosome
Accession NZ_CP100482
Organism Klebsiella grimontii strain LH87-a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NLZ17_RS28050 Protein ID WP_098363641.1
Coordinates 5850877..5851251 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NLZ17_RS28055 Protein ID WP_077265771.1
Coordinates 5851248..5851487 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ17_RS28035 (NLZ17_28035) 5848032..5848934 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
NLZ17_RS28040 (NLZ17_28040) 5848931..5849566 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
NLZ17_RS28045 (NLZ17_28045) 5849910..5850839 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
NLZ17_RS28050 (NLZ17_28050) 5850877..5851251 - 375 WP_098363641.1 type II toxin-antitoxin system VapC family toxin Toxin
NLZ17_RS28055 (NLZ17_28055) 5851248..5851487 - 240 WP_077265771.1 CopG family transcriptional regulator Antitoxin
NLZ17_RS28060 (NLZ17_28060) 5851693..5852610 + 918 WP_024360706.1 alpha/beta hydrolase -
NLZ17_RS28065 (NLZ17_28065) 5852628..5853569 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
NLZ17_RS28070 (NLZ17_28070) 5853614..5854051 - 438 WP_004132870.1 D-aminoacyl-tRNA deacylase -
NLZ17_RS28075 (NLZ17_28075) 5854048..5854908 - 861 WP_024360708.1 virulence factor BrkB family protein -
NLZ17_RS28080 (NLZ17_28080) 5854902..5855501 - 600 WP_024360709.1 glucose-1-phosphatase -
NLZ17_RS28085 (NLZ17_28085) 5855631..5856416 - 786 WP_064342034.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14081.36 Da        Isoelectric Point: 8.4571

>T250607 WP_098363641.1 NZ_CP100482:c5851251-5850877 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWTEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9307.51 Da        Isoelectric Point: 4.3253

>AT250607 WP_077265771.1 NZ_CP100482:c5851487-5851248 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEEGVEFERKLREEWQ

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References