Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2873430..2874211 Replicon chromosome
Accession NC_014923
Organism Mesorhizobium ciceri biovar biserrulae WSM1271

Toxin (Protein)


Gene name TacT2 Uniprot ID E8T9Q8
Locus tag MESCI_RS13825 Protein ID WP_013530563.1
Coordinates 2873430..2873924 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID E8T9Q9
Locus tag MESCI_RS13830 Protein ID WP_013530564.1
Coordinates 2873921..2874211 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MESCI_RS13795 2868697..2869503 - 807 WP_013530558.1 ABC transporter substrate-binding protein -
MESCI_RS13800 2869614..2870777 - 1164 WP_013530559.1 saccharopine dehydrogenase family protein -
MESCI_RS13805 2870774..2871274 - 501 WP_013530560.1 Lrp/AsnC family transcriptional regulator -
MESCI_RS13810 2871406..2872278 - 873 WP_013530561.1 LysR family transcriptional regulator -
MESCI_RS13815 2872417..2872623 + 207 WP_063168653.1 hypothetical protein -
MESCI_RS13820 2872645..2873394 + 750 WP_013530562.1 sulfite exporter TauE/SafE family protein -
MESCI_RS13825 2873430..2873924 - 495 WP_013530563.1 GNAT family N-acetyltransferase Toxin
MESCI_RS13830 2873921..2874211 - 291 WP_013530564.1 DUF1778 domain-containing protein Antitoxin
MESCI_RS13835 2874298..2874747 - 450 WP_013530565.1 universal stress protein -
MESCI_RS13840 2874954..2875535 + 582 WP_013530566.1 histidine phosphatase family protein -
MESCI_RS13845 2875565..2875966 - 402 WP_013530567.1 VOC family protein -
MESCI_RS13850 2876087..2876839 - 753 WP_013530568.1 rRNA pseudouridine synthase -
MESCI_RS13855 2876998..2877444 + 447 WP_013530569.1 SRPBCC domain-containing protein -
MESCI_RS13860 2877486..2878328 - 843 WP_013530570.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17512.16 Da        Isoelectric Point: 8.0629

>T25060 WP_013530563.1 NC_014923:c2873924-2873430 [Mesorhizobium ciceri biovar biserrulae WSM1271]
VTLSVPVPLADHHELGEFSSGITALDDWLKKRARTNQAGGASRTYVTCKGNRVIGYYAVASGAVKMVEASSRFRRDMPDP
IPVAVLGRLAVDQAYHGRGIGRALVRDAGLRILQAAEILGIKGIVVHAISDDARAFYITIGFEPSPVEPLTLMVTLADLS
ESIG

Download         Length: 495 bp

>T25060 NC_014923:c2873924-2873430 [Mesorhizobium ciceri biovar biserrulae WSM1271]
GTGACGCTGTCGGTCCCGGTTCCACTCGCGGATCATCACGAACTCGGGGAATTTTCGTCGGGCATTACAGCGCTCGACGA
TTGGTTGAAAAAACGTGCTCGCACCAATCAAGCGGGCGGTGCATCCCGGACCTATGTGACTTGCAAAGGCAACCGTGTGA
TTGGCTACTATGCCGTTGCCAGCGGCGCCGTGAAAATGGTCGAAGCTTCCAGCCGTTTCCGGCGCGACATGCCCGATCCG
ATCCCCGTCGCAGTGCTAGGCAGGTTGGCCGTAGACCAAGCCTATCACGGTCGGGGCATCGGTCGGGCGCTGGTAAGGGA
TGCCGGTCTACGAATTCTCCAGGCTGCTGAAATACTGGGCATCAAAGGCATAGTGGTGCATGCGATTTCCGACGATGCCC
GAGCTTTCTACATCACCATCGGGTTCGAGCCCTCGCCGGTCGAGCCGTTGACACTCATGGTCACGCTCGCTGATCTCAGC
GAAAGCATTGGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10842.51 Da        Isoelectric Point: 9.9898

>AT25060 WP_013530564.1 NC_014923:c2874211-2873921 [Mesorhizobium ciceri biovar biserrulae WSM1271]
MPTSHHPVPKSVPLNIRVKPEVRNLIDRAAELLGKNRTDFMLEASQRAAEEALLNRLVFTVEPDVYAAFLARLDAPPQPN
DRLRRTMTTKAPWEAA

Download         Length: 291 bp

>AT25060 NC_014923:c2874211-2873921 [Mesorhizobium ciceri biovar biserrulae WSM1271]
ATGCCAACGTCACATCATCCGGTGCCGAAGAGCGTTCCGCTCAACATCCGCGTCAAGCCGGAAGTTCGCAATCTGATCGA
CCGCGCAGCCGAATTGCTCGGTAAGAATCGCACCGACTTCATGCTTGAAGCCTCGCAACGCGCCGCTGAGGAAGCGTTGC
TCAACCGTCTCGTGTTTACCGTCGAACCGGATGTCTACGCTGCGTTTCTGGCACGCCTCGACGCGCCGCCGCAGCCCAAC
GACCGATTGCGCCGCACGATGACGACAAAGGCTCCGTGGGAAGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E8T9Q8

Antitoxin

Source ID Structure
AlphaFold DB A0A3S2IG73

References