Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 900034..900691 Replicon chromosome
Accession NZ_CP100482
Organism Klebsiella grimontii strain LH87-a

Toxin (Protein)


Gene name cptA Uniprot ID A0A9E1DA00
Locus tag NLZ17_RS04415 Protein ID WP_024358614.1
Coordinates 900281..900691 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag NLZ17_RS04410 Protein ID WP_004124953.1
Coordinates 900034..900300 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ17_RS04395 (NLZ17_04395) 895286..895711 - 426 WP_024358617.1 PTS sugar transporter subunit IIA -
NLZ17_RS04400 (NLZ17_04400) 895832..898630 - 2799 WP_154930991.1 transcriptional regulator DagR -
NLZ17_RS04405 (NLZ17_04405) 898806..899789 - 984 WP_024358615.1 tRNA-modifying protein YgfZ -
NLZ17_RS04410 (NLZ17_04410) 900034..900300 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
NLZ17_RS04415 (NLZ17_04415) 900281..900691 + 411 WP_024358614.1 protein YgfX Toxin
NLZ17_RS04420 (NLZ17_04420) 900700..901221 - 522 WP_024358613.1 flavodoxin FldB -
NLZ17_RS04425 (NLZ17_04425) 901343..902239 + 897 WP_154930993.1 site-specific tyrosine recombinase XerD -
NLZ17_RS04430 (NLZ17_04430) 902262..902975 + 714 WP_004134425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ17_RS04435 (NLZ17_04435) 902981..904714 + 1734 WP_098066860.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.97 Da        Isoelectric Point: 10.9455

>T250599 WP_024358614.1 NZ_CP100482:900281-900691 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWEIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT250599 WP_004124953.1 NZ_CP100482:900034-900300 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References