Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 815815..816593 Replicon chromosome
Accession NZ_CP100482
Organism Klebsiella grimontii strain LH87-a

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NLZ17_RS03990 Protein ID WP_154931156.1
Coordinates 816105..816593 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag NLZ17_RS03985 Protein ID WP_105490942.1
Coordinates 815815..816108 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ17_RS03970 (NLZ17_03970) 810971..812116 - 1146 WP_098066871.1 PLP-dependent aspartate aminotransferase family protein -
NLZ17_RS03975 (NLZ17_03975) 812127..813497 - 1371 WP_101868001.1 cystathionine beta-synthase -
NLZ17_RS03980 (NLZ17_03980) 814043..815431 + 1389 WP_049085001.1 DASS family sodium-coupled anion symporter -
NLZ17_RS03985 (NLZ17_03985) 815815..816108 + 294 WP_105490942.1 DUF1778 domain-containing protein Antitoxin
NLZ17_RS03990 (NLZ17_03990) 816105..816593 + 489 WP_154931156.1 GNAT family N-acetyltransferase Toxin
NLZ17_RS03995 (NLZ17_03995) 816773..817225 - 453 WP_203260018.1 hypothetical protein -
NLZ17_RS04000 (NLZ17_04000) 817303..817557 - 255 WP_203260017.1 hypothetical protein -
NLZ17_RS04005 (NLZ17_04005) 817729..818430 - 702 WP_236051879.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17532.39 Da        Isoelectric Point: 8.1476

>T250598 WP_154931156.1 NZ_CP100482:816105-816593 [Klebsiella grimontii]
MISTPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMMTLGDLV
NA

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10932.58 Da        Isoelectric Point: 9.8590

>AT250598 WP_105490942.1 NZ_CP100482:815815-816108 [Klebsiella grimontii]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References