Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 36520..37430 | Replicon | plasmid pLH99-d-A |
| Accession | NZ_CP100479 | ||
| Organism | Klebsiella pneumoniae strain LH99-d | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | NLZ18_RS25415 | Protein ID | WP_004026354.1 |
| Coordinates | 36960..37430 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A7H4PRG4 |
| Locus tag | NLZ18_RS25410 | Protein ID | WP_032413443.1 |
| Coordinates | 36520..36963 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NLZ18_RS25390 (NLZ18_25390) | 31738..32445 | + | 708 | WP_048268734.1 | hypothetical protein | - |
| NLZ18_RS25395 (NLZ18_25395) | 32450..33481 | + | 1032 | WP_170919122.1 | CRISPR-associated protein Csf2 | - |
| NLZ18_RS25400 (NLZ18_25400) | 34727..35149 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NLZ18_RS25405 (NLZ18_25405) | 35149..36420 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NLZ18_RS25410 (NLZ18_25410) | 36520..36963 | + | 444 | WP_032413443.1 | DUF2384 domain-containing protein | Antitoxin |
| NLZ18_RS25415 (NLZ18_25415) | 36960..37430 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| NLZ18_RS25420 (NLZ18_25420) | 37540..37800 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| NLZ18_RS25425 (NLZ18_25425) | 38499..39868 | + | 1370 | WP_085949440.1 | IS3-like element ISKpn8 family transposase | - |
| NLZ18_RS25430 (NLZ18_25430) | 40028..41560 | - | 1533 | WP_004118819.1 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..224564 | 224564 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T250596 WP_004026354.1 NZ_CP100479:36960-37430 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16508.82 Da Isoelectric Point: 10.3013
>AT250596 WP_032413443.1 NZ_CP100479:36520-36963 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7H4PRG4 |