Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4640474..4640990 Replicon chromosome
Accession NZ_CP100478
Organism Klebsiella pneumoniae strain LH99-d

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NLZ18_RS22490 Protein ID WP_040237797.1
Coordinates 4640474..4640758 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NLZ18_RS22495 Protein ID WP_002886901.1
Coordinates 4640748..4640990 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ18_RS22465 (4635877) 4635877..4636140 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
NLZ18_RS22470 (4636270) 4636270..4636443 + 174 WP_032412860.1 hypothetical protein -
NLZ18_RS22475 (4636446) 4636446..4637189 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NLZ18_RS22480 (4637546) 4637546..4639684 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
NLZ18_RS22485 (4640006) 4640006..4640470 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NLZ18_RS22490 (4640474) 4640474..4640758 - 285 WP_040237797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ18_RS22495 (4640748) 4640748..4640990 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NLZ18_RS22500 (4641068) 4641068..4642978 - 1911 WP_117054542.1 PRD domain-containing protein -
NLZ18_RS22505 (4643001) 4643001..4644155 - 1155 WP_040237796.1 lactonase family protein -
NLZ18_RS22510 (4644222) 4644222..4644962 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11067.91 Da        Isoelectric Point: 10.4962

>T250593 WP_040237797.1 NZ_CP100478:c4640758-4640474 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250593 WP_002886901.1 NZ_CP100478:c4640990-4640748 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References