Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2610072..2611660 Replicon chromosome
Accession NZ_CP100478
Organism Klebsiella pneumoniae strain LH99-d

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NLZ18_RS12865 Protein ID WP_004199851.1
Coordinates 2610072..2611394 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NLZ18_RS12870 Protein ID WP_002904790.1
Coordinates 2611394..2611660 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ18_RS12850 (2605128) 2605128..2607629 + 2502 WP_100292022.1 fimbria/pilus outer membrane usher protein -
NLZ18_RS12855 (2607617) 2607617..2608621 + 1005 WP_100292021.1 fimbrial protein -
NLZ18_RS12860 (2608763) 2608763..2610055 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NLZ18_RS12865 (2610072) 2610072..2611394 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NLZ18_RS12870 (2611394) 2611394..2611660 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NLZ18_RS12875 (2612047) 2612047..2612373 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NLZ18_RS12880 (2612370) 2612370..2612870 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NLZ18_RS12885 (2612848) 2612848..2614227 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NLZ18_RS12890 (2614573) 2614573..2615727 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NLZ18_RS12895 (2615708) 2615708..2616631 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T250590 WP_004199851.1 NZ_CP100478:c2611394-2610072 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT250590 WP_002904790.1 NZ_CP100478:c2611660-2611394 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References