Detailed information of TA system TA025059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 1585572..1586225
• Replicon: chromosome
• Accession: NC_014922
• Organism: Haemophilus influenzae F3047

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HICON_RS07845
• Protein ID: WP_006996056.1
• Coordinates: 1585572..1585964 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5C2R5S0
• Locus tag: HICON_RS07850
• Protein ID: WP_006996057.1
• Coordinates: 1585965..1586225 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HICON_RS07830	1581432..1581863	-	432	WP_013527703.1	YcgN family cysteine cluster protein	-
HICON_RS07835	1581942..1583609	-	1668	WP_013527704.1	glutamine--tRNA ligase	-
HICON_RS10305	1583806..1585222	-	1417	Protein_1515	YadA-like family protein	-
HICON_RS07845	1585572..1585964	-	393	WP_006996056.1	type II toxin-antitoxin system VapC family toxin	Toxin
HICON_RS07850	1585965..1586225	-	261	WP_006996057.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HICON_RS07855	1586308..1587783	-	1476	WP_006996058.1	ribonuclease G	-
HICON_RS07860	1587898..1589412	+	1515	WP_006996059.1	sodium/proline symporter PutP	-
HICON_RS07865	1589409..1590374	+	966	WP_006996060.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14758.20 Da
• Isoelectric Point: 4.6908

>T25059 WP_006996056.1 NC_014922:c1585964-1585572 [Haemophilus influenzae F3047]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFEFVPNLILENWCSV

Nucleotide

• Length: 393 bp

>T25059 NC_014922:c1585964-1585572 [Haemophilus influenzae F3047]
ATGTATATGTTAGATACGAATACTGTGAGTTATTTTTTCCGTAAAGTGCCTTCTGTAGTAGAACGATTAAGGCTGCTTAA
TCCTGAAATTCTCTGTATTTCTTCTGTTACCGCCGCTGAATTATTTTATGGTGTGGCAAAGCGTAATAATCTGCAACTTT
CACAGTTTCTAGATATATTTTTATCTGCGATTTCTATTTTAGAATGGGATACGAAAACCGCTGAAATTTATGGCAAGCTA
AGAGCTGAAATGGAAAAAGAAGGCAAAGTAATGGGCGTACAAGATCAGATGATTGCTGCTCACGCTTTAGCTAATGAATG
TGTTTTAGTCACGAGTGATAAAGCTTTTGAGTTTGTCCCCAACTTGATTTTAGAAAATTGGTGTAGTGTTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10301.56 Da
• Isoelectric Point: 4.9010

>AT25059 WP_006996057.1 NC_014922:c1586225-1585965 [Haemophilus influenzae F3047]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Nucleotide

• Length: 261 bp

>AT25059 NC_014922:c1586225-1585965 [Haemophilus influenzae F3047]
ATGGAAAAAATCGCACGTTTATTTAGAAATGGTCGCAATCAAGCCGTTCGTTTACCTGTGGAATTTGAGTTTGACGCCAC
TCAAATTTATGTTTTCAAAGAAGAAAATGGCGATATTAGGCTTTCAACTCGTTCTCGTAGCCAGCAAAATTGGCAGAAAG
TCTTCGAATTGTTACCTACAATTCAATGTGATGAAGATTTTTTATCAGAAAAAGAGCGTAAGCAAGAAGTGGCAACGCGA
GATCCTTTTGAGGGCTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5C2R5S0