Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812070..812727 Replicon chromosome
Accession NZ_CP100478
Organism Klebsiella pneumoniae strain LH99-d

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NLZ18_RS04100 Protein ID WP_002916310.1
Coordinates 812317..812727 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NLZ18_RS04095 Protein ID WP_002916312.1
Coordinates 812070..812336 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ18_RS04070 (807226) 807226..808659 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NLZ18_RS04075 (808778) 808778..809506 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NLZ18_RS04080 (809556) 809556..809867 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NLZ18_RS04085 (810031) 810031..810690 + 660 WP_002916317.1 hemolysin III family protein -
NLZ18_RS04090 (810841) 810841..811824 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
NLZ18_RS04095 (812070) 812070..812336 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NLZ18_RS04100 (812317) 812317..812727 + 411 WP_002916310.1 protein YgfX Toxin
NLZ18_RS04105 (812734) 812734..813255 - 522 WP_002916308.1 flavodoxin FldB -
NLZ18_RS04110 (813356) 813356..814252 + 897 WP_004185550.1 site-specific tyrosine recombinase XerD -
NLZ18_RS04115 (814275) 814275..814988 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ18_RS04120 (814994) 814994..816727 + 1734 WP_004185546.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250585 WP_002916310.1 NZ_CP100478:812317-812727 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250585 WP_002916312.1 NZ_CP100478:812070-812336 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References