Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4977780..4978447 Replicon chromosome
Accession NZ_CP100476
Organism Mesorhizobium sp. C120A

Toxin (Protein)


Gene name vapC Uniprot ID V7HJC5
Locus tag NL532_RS24440 Protein ID WP_023689057.1
Coordinates 4977780..4978196 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V7HL59
Locus tag NL532_RS24445 Protein ID WP_023670289.1
Coordinates 4978193..4978447 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL532_RS24405 (NL532_24360) 4973058..4973279 + 222 WP_023829011.1 hypothetical protein -
NL532_RS24410 (NL532_24365) 4973282..4973536 - 255 WP_023829012.1 DUF982 domain-containing protein -
NL532_RS24415 (NL532_24370) 4973599..4974819 + 1221 WP_023829013.1 RNA-guided endonuclease TnpB family protein -
NL532_RS24420 (NL532_24375) 4975063..4976142 + 1080 WP_050590953.1 site-specific integrase -
NL532_RS24430 (NL532_24385) 4976521..4976820 + 300 WP_023829015.1 hypothetical protein -
NL532_RS24435 (NL532_24390) 4977212..4977472 + 261 WP_023689056.1 hypothetical protein -
NL532_RS24440 (NL532_24395) 4977780..4978196 - 417 WP_023689057.1 type II toxin-antitoxin system VapC family toxin Toxin
NL532_RS24445 (NL532_24400) 4978193..4978447 - 255 WP_023670289.1 plasmid stabilization protein Antitoxin
NL532_RS24450 (NL532_24405) 4978571..4979275 - 705 WP_023689058.1 DnaA regulatory inactivator HdaA -
NL532_RS24455 (NL532_24410) 4979278..4980471 - 1194 WP_023684761.1 AI-2E family transporter -
NL532_RS24460 (NL532_24415) 4980443..4980998 - 556 Protein_4838 CDP-alcohol phosphatidyltransferase family protein -
NL532_RS24465 (NL532_24420) 4981186..4982265 + 1080 WP_023689059.1 phosphoribosylformylglycinamidine cyclo-ligase -
NL532_RS24470 (NL532_24425) 4982262..4982969 + 708 WP_023689060.1 phosphoribosylglycinamide formyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14814.00 Da        Isoelectric Point: 5.5797

>T250582 WP_023689057.1 NZ_CP100476:c4978196-4977780 [Mesorhizobium sp. C120A]
MILLDTNVVSEAMKPEPHQAVLAWLDDQAEETLYLSSVTLAEVLFGIEAMPAGRRKAALAETFAGVCAVFERRILPFDTE
AARHYARLAVKARAAGKGFPVPDGYIAAIASANGFHLASRDTAPFHAAGVPVIDPWQP

Download         Length: 417 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9177.42 Da        Isoelectric Point: 6.4714

>AT250582 WP_023670289.1 NZ_CP100476:c4978447-4978193 [Mesorhizobium sp. C120A]
MPAVTVRNLPEATHRALRVRAALHGRSTEAEIRDILENAVRPDGRVKLGSVLADIARRAGLTNEDVEVLEQARDKAPAEP
LGFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HJC5

Antitoxin

Source ID Structure
AlphaFold DB V7HL59

References