Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2779599..2780260 Replicon chromosome
Accession NZ_CP100476
Organism Mesorhizobium sp. C120A

Toxin (Protein)


Gene name vapC Uniprot ID V7HJQ8
Locus tag NL532_RS13420 Protein ID WP_023682204.1
Coordinates 2779823..2780260 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V7HJ89
Locus tag NL532_RS13415 Protein ID WP_023829221.1
Coordinates 2779599..2779826 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL532_RS13400 (NL532_13380) 2774987..2776021 + 1035 WP_023668188.1 ABC transporter permease -
NL532_RS13405 (NL532_13385) 2776035..2777192 + 1158 WP_023668189.1 ABC transporter permease -
NL532_RS13410 (NL532_13390) 2777240..2779456 + 2217 WP_023729392.1 ABC transporter ATP-binding protein -
NL532_RS13415 (NL532_13395) 2779599..2779826 + 228 WP_023829221.1 hypothetical protein Antitoxin
NL532_RS13420 (NL532_13400) 2779823..2780260 + 438 WP_023682204.1 PIN domain-containing protein Toxin
NL532_RS13425 (NL532_13405) 2780317..2780907 - 591 WP_023829222.1 transglycosylase SLT domain-containing protein -
NL532_RS13430 (NL532_13410) 2781124..2782662 + 1539 WP_023829223.1 trimethylamine methyltransferase family protein -
NL532_RS13435 (NL532_13415) 2782741..2785182 + 2442 WP_023682201.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15576.77 Da        Isoelectric Point: 6.8429

>T250580 WP_023682204.1 NZ_CP100476:2779823-2780260 [Mesorhizobium sp. C120A]
VTFLLDVNVLIALIDPAHVAHEDAHRWFQSTGHLSWATCPITENGVIRIVSNPKYPNSPGSPAVVAQIVGKLHALSGHQF
WPDEISLVGSNDIDAARILTPAQVTDSYLLGLAKARDGQLATFDRKLSTAAVKGGRSILHLIPSE

Download         Length: 438 bp

>T250580 NZ_CP100476:2779823-2780260 [Mesorhizobium sp. C120A]
GTGACCTTCCTGCTCGACGTCAATGTGTTGATTGCGTTGATCGATCCGGCTCACGTCGCGCATGAAGATGCCCATCGGTG
GTTCCAGTCCACCGGGCATTTATCATGGGCAACATGTCCCATTACCGAGAATGGCGTCATCAGGATTGTAAGCAACCCGA
AATACCCCAATTCTCCGGGTTCGCCCGCCGTGGTGGCGCAGATTGTCGGCAAGCTGCATGCCCTTTCAGGACATCAGTTC
TGGCCTGACGAGATCAGCCTTGTCGGTTCCAACGACATCGATGCAGCCAGGATCCTCACCCCGGCACAGGTAACGGATAG
CTATCTGTTGGGACTCGCCAAGGCGCGTGACGGCCAATTGGCGACGTTTGACCGAAAGCTGTCGACGGCAGCGGTAAAGG
GAGGGAGGTCGATCCTCCACCTGATCCCAAGCGAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8193.37 Da        Isoelectric Point: 5.0152

>AT250580 WP_023829221.1 NZ_CP100476:2779599-2779826 [Mesorhizobium sp. C120A]
VRTTLAIDDDVLLAAKAMARQQDRSVGDVISDLARRSLRRPPTGGERNGIPLLASRPDSPMVDLEMVNALRDELP

Download         Length: 228 bp

>AT250580 NZ_CP100476:2779599-2779826 [Mesorhizobium sp. C120A]
GTGAGAACCACACTTGCAATCGATGACGATGTCCTACTTGCGGCCAAGGCCATGGCGCGACAGCAGGATCGCAGCGTTGG
CGACGTCATTTCCGATCTGGCTCGCCGCTCACTGCGCAGGCCCCCGACCGGCGGTGAACGCAACGGCATCCCCTTGCTTG
CATCGCGGCCCGACAGCCCGATGGTCGATCTCGAAATGGTCAATGCGCTTCGCGACGAATTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HJQ8

Antitoxin

Source ID Structure
AlphaFold DB V7HJ89

References