Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2132549..2133177 Replicon chromosome
Accession NZ_CP100476
Organism Mesorhizobium sp. C120A

Toxin (Protein)


Gene name vapC Uniprot ID V7HPF9
Locus tag NL532_RS10455 Protein ID WP_023724991.1
Coordinates 2132791..2133177 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID X6KRM4
Locus tag NL532_RS10450 Protein ID WP_023724992.1
Coordinates 2132549..2132794 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL532_RS10420 (NL532_10405) 2127658..2128410 - 753 WP_023669968.1 SDR family NAD(P)-dependent oxidoreductase -
NL532_RS10425 (NL532_10410) 2128456..2129544 - 1089 WP_023754959.1 AbrB family transcriptional regulator -
NL532_RS10430 (NL532_10415) 2129625..2129933 - 309 WP_023691624.1 putative quinol monooxygenase -
NL532_RS10435 (NL532_10420) 2130013..2130792 - 780 WP_023686180.1 SDR family oxidoreductase -
NL532_RS10440 (NL532_10425) 2130866..2131294 - 429 WP_023754958.1 DsrE family protein -
NL532_RS10445 (NL532_10430) 2131395..2132483 + 1089 WP_023754957.1 hypothetical protein -
NL532_RS10450 (NL532_10435) 2132549..2132794 + 246 WP_023724992.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NL532_RS10455 (NL532_10440) 2132791..2133177 + 387 WP_023724991.1 type II toxin-antitoxin system VapC family toxin Toxin
NL532_RS10460 (NL532_10445) 2133184..2134131 - 948 WP_023754956.1 cation diffusion facilitator family transporter -
NL532_RS10465 (NL532_10450) 2134137..2136326 - 2190 WP_023828139.1 anthranilate synthase -
NL532_RS10470 (NL532_10455) 2136647..2137417 + 771 WP_023695831.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14208.29 Da        Isoelectric Point: 5.6660

>T250577 WP_023724991.1 NZ_CP100476:2132791-2133177 [Mesorhizobium sp. C120A]
VTYLLDTNAVIAIIAGDEGLLALLKRHAPQDFALSAVVLHELYYGAEKSQRKVQNLARIEALQFPVLEFDRDDARHAGEI
RAGLAALGTPIGPYDALIGGQARARDLTLITRNIREFERIKDLTIETW

Download         Length: 387 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9354.49 Da        Isoelectric Point: 4.4609

>AT250577 WP_023724992.1 NZ_CP100476:2132549-2132794 [Mesorhizobium sp. C120A]
MDKAKVFWSGRSQAVRLPKEFRFEADEVSIRRHGQTVILEPLAQDWAWLDQVIGPVDDDFVQGALERQDGQDRPALDDLF
K

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HPF9

Antitoxin

Source ID Structure
AlphaFold DB X6KRM4

References