Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 507249..507931 Replicon chromosome
Accession NZ_CP100476
Organism Mesorhizobium sp. C120A

Toxin (Protein)


Gene name vapC Uniprot ID V7HM72
Locus tag NL532_RS02410 Protein ID WP_023805773.1
Coordinates 507249..507671 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V7HMR4
Locus tag NL532_RS02415 Protein ID WP_023702090.1
Coordinates 507668..507931 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL532_RS02385 (NL532_02385) 503182..503880 - 699 WP_023672341.1 YafY family protein -
NL532_RS02390 (NL532_02390) 504007..504642 + 636 WP_023732715.1 LysE family translocator -
NL532_RS02395 (NL532_02395) 504756..505271 - 516 WP_023805772.1 SRPBCC domain-containing protein -
NL532_RS02400 (NL532_02400) 505249..505608 - 360 WP_023687408.1 helix-turn-helix domain-containing protein -
NL532_RS02405 (NL532_02405) 505684..506775 - 1092 WP_023732717.1 3-deoxy-7-phosphoheptulonate synthase -
NL532_RS02410 (NL532_02410) 507249..507671 - 423 WP_023805773.1 type II toxin-antitoxin system VapC family toxin Toxin
NL532_RS02415 (NL532_02415) 507668..507931 - 264 WP_023702090.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL532_RS02420 (NL532_02420) 508004..508798 - 795 WP_023805774.1 SDR family oxidoreductase -
NL532_RS02425 (NL532_02425) 508829..509824 - 996 WP_023805775.1 inositol 2-dehydrogenase -
NL532_RS02430 (NL532_02430) 509938..510720 - 783 WP_027049093.1 ATP-binding cassette domain-containing protein -
NL532_RS02435 (NL532_02435) 510723..511799 - 1077 WP_023710443.1 ABC transporter permease -
NL532_RS02440 (NL532_02440) 511907..512848 - 942 WP_023684065.1 sugar ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-69)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15627.90 Da        Isoelectric Point: 5.0029

>T250576 WP_023805773.1 NZ_CP100476:c507671-507249 [Mesorhizobium sp. C120A]
VRLLLDTNVLSEVTRPAPVARVLGWLDELDEDRSFISVVSIAEIRRGVSLMDEGRKREALAEWLARDLPQRFEQRVLPVD
DAVALAWGDLMGFGKRRGRGLSSMDGLIAATAIAHELTLATRNTKHFEGFGLELFDPWTA

Download         Length: 423 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9658.96 Da        Isoelectric Point: 10.4718

>AT250576 WP_023702090.1 NZ_CP100476:c507931-507668 [Mesorhizobium sp. C120A]
MLTSSKGTNWTVAGAKARLSEVIERAQSSPQTITKNGKPSVVVVSAEEWQRKIARKGTLAEFLLDSPLRGADLDLERQRD
EPRDLPR

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HM72

Antitoxin

Source ID Structure
AlphaFold DB V7HMR4

References