250575

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 296230..296782 Replicon chromosome
Accession NZ_CP100476
Organism Mesorhizobium sp. C120A

Toxin (Protein)


Gene name brnT Uniprot ID V7HIW4
Locus tag NL532_RS01390 Protein ID WP_023755803.1
Coordinates 296230..296484 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID V7HH53
Locus tag NL532_RS01395 Protein ID WP_023755802.1
Coordinates 296471..296782 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL532_RS01375 (NL532_01375) 291345..292304 - 960 WP_023671388.1 ABC transporter permease -
NL532_RS01380 (NL532_01380) 292321..293907 - 1587 WP_023755805.1 ABC transporter substrate-binding protein -
NL532_RS01385 (NL532_01385) 294062..296047 - 1986 WP_023755804.1 CocE/NonD family hydrolase -
NL532_RS01390 (NL532_01390) 296230..296484 + 255 WP_023755803.1 BrnT family toxin Toxin
NL532_RS01395 (NL532_01395) 296471..296782 + 312 WP_023755802.1 BrnA antitoxin family protein Antitoxin
NL532_RS01400 (NL532_01400) 296793..297386 - 594 WP_023671383.1 nucleoside deaminase -
NL532_RS01405 (NL532_01405) 297390..297890 - 501 WP_023755801.1 ureidoglycolate lyase -
NL532_RS01410 (NL532_01410) 297887..298750 - 864 WP_023755800.1 bifunctional allantoicase/(S)-ureidoglycine aminohydrolase -
NL532_RS01415 (NL532_01415) 298777..300195 - 1419 WP_023755799.1 allantoinase PuuE -
NL532_RS01420 (NL532_01420) 300380..300754 + 375 WP_023694734.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-77)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9526.98 Da        Isoelectric Point: 6.3419

>T250575 WP_023755803.1 NZ_CP100476:296230-296484 [Mesorhizobium sp. C120A]
MKIVWDEPKRVTNLDSRGLDFAELDIEFFATSTVFPAKADRFKAIGEFGEIILAVIFKPLGSEAISVISMRRASRKERSV
YEQS

Download         Length: 255 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11724.24 Da        Isoelectric Point: 7.0203

>AT250575 WP_023755802.1 NZ_CP100476:296471-296782 [Mesorhizobium sp. C120A]
MNNHKSRVRPLTDAEEVEIQRQIVDDPDDAETTDEQLAQARPFAEVFPELFESIRRARGRPAVEKPKQVVSIRLDQDVIS
KFKATGKGWQARINEVLKNAKVG

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HIW4

Antitoxin

Source ID Structure
AlphaFold DB V7HH53

References