Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 5653367..5653949 Replicon chromosome
Accession NZ_CP100475
Organism Mesorhizobium sp. C372A

Toxin (Protein)


Gene name PumA Uniprot ID X6KG12
Locus tag NLY42_RS27325 Protein ID WP_023672746.1
Coordinates 5653662..5653949 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID X6KDU4
Locus tag NLY42_RS27320 Protein ID WP_023672747.1
Coordinates 5653367..5653660 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY42_RS27290 (NLY42_27275) 5648688..5649134 - 447 WP_023747898.1 hypothetical protein -
NLY42_RS27295 (NLY42_27280) 5649337..5649759 - 423 WP_023747899.1 glyoxalase -
NLY42_RS27300 (NLY42_27285) 5649747..5650223 - 477 WP_156933781.1 MarR family transcriptional regulator -
NLY42_RS27305 (NLY42_27290) 5650498..5651346 - 849 WP_023747902.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
NLY42_RS27310 (NLY42_27295) 5651354..5651968 - 615 WP_023754721.1 hypothetical protein -
NLY42_RS27315 (NLY42_27300) 5652151..5653308 + 1158 WP_031243043.1 hypothetical protein -
NLY42_RS27320 (NLY42_27305) 5653367..5653660 - 294 WP_023672747.1 putative addiction module antidote protein Antitoxin
NLY42_RS27325 (NLY42_27310) 5653662..5653949 - 288 WP_023672746.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLY42_RS27330 (NLY42_27315) 5654002..5655006 - 1005 WP_023754722.1 Rieske (2Fe-2S) protein -
NLY42_RS27335 (NLY42_27320) 5655003..5656136 - 1134 WP_023756429.1 GNAT family N-acetyltransferase -
NLY42_RS27340 (NLY42_27325) 5656133..5657389 - 1257 WP_023754724.1 coenzyme F390 synthetase -
NLY42_RS27345 (NLY42_27330) 5657386..5658210 - 825 WP_023754725.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10788.59 Da        Isoelectric Point: 10.6803

>T250574 WP_023672746.1 NZ_CP100475:c5653949-5653662 [Mesorhizobium sp. C372A]
MIEVRSTDEFRKWLRGLTDIRAVKKITQRIVRVQAGLLGDAKFFDGIGELRVDYGPGYRVYFVRRGNTVIILLCGGDKGS
QDRDIGKARKMAKEV

Download         Length: 288 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10221.63 Da        Isoelectric Point: 4.7527

>AT250574 WP_023672747.1 NZ_CP100475:c5653660-5653367 [Mesorhizobium sp. C372A]
MTLRTTPFDAAEYLDDAESQAELLADAFETGDATYIAHALGIVARARGMTSIAKDAGVTREALYKALSEKGDPRLSTLLG
VTKALGLQLSAKPVNPV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X6KG12

Antitoxin

Source ID Structure
AlphaFold DB X6KDU4

References