250573

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 4795228..4795639 Replicon chromosome
Accession NZ_CP100475
Organism Mesorhizobium sp. C372A

Toxin (Protein)


Gene name hicA Uniprot ID X6KMY1
Locus tag NLY42_RS23025 Protein ID WP_023669047.1
Coordinates 4795228..4795428 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID X6KJU0
Locus tag NLY42_RS23030 Protein ID WP_023669048.1
Coordinates 4795433..4795639 (+) Length 69 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY42_RS23020 (NLY42_23010) 4791457..4795221 + 3765 WP_023754399.1 vitamin B12-dependent ribonucleotide reductase -
NLY42_RS23025 (NLY42_23015) 4795228..4795428 + 201 WP_023669047.1 type II toxin-antitoxin system HicA family toxin Toxin
NLY42_RS23030 (NLY42_23020) 4795433..4795639 + 207 WP_023669048.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NLY42_RS23035 (NLY42_23025) 4795663..4796268 - 606 WP_245263524.1 hypothetical protein -
NLY42_RS23040 (NLY42_23030) 4796273..4796809 - 537 WP_245263523.1 hypothetical protein -
NLY42_RS23045 (NLY42_23035) 4796823..4797518 - 696 WP_245263522.1 DUF3592 domain-containing protein -
NLY42_RS23050 (NLY42_23040) 4797558..4797794 - 237 WP_245263521.1 hypothetical protein -
NLY42_RS23055 (NLY42_23045) 4797958..4798899 + 942 WP_023754396.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NLY42_RS23060 (NLY42_23050) 4798920..4799804 - 885 WP_023669052.1 DMT family transporter -
NLY42_RS23065 (NLY42_23055) 4799801..4800409 - 609 WP_023669053.1 class I SAM-dependent methyltransferase -
NLY42_RS23070 (NLY42_23060) 4800438..4800611 - 174 WP_023669054.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4791457..4809058 17601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 67 a.a.        Molecular weight: 7328.51 Da        Isoelectric Point: 10.7459

>T250573 WP_023669047.1 NZ_CP100475:4795228-4795428 [Mesorhizobium sp. C372A]
MPPRLTVREVIRLLETDGWYLVATKGSHRQYKHKTKAGRVTVAGKPSEEVAPGTLNSILKQSGLKE

Download         Length: 201 bp


Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7346.40 Da        Isoelectric Point: 4.3178

>AT250573 WP_023669048.1 NZ_CP100475:4795433-4795639 [Mesorhizobium sp. C372A]
MRYAVVIEKAGNNFSAYVPDLPGCIATGATVPEVEIEIRDAIRFHIEGLRADGLEVPKGISLAEYVEA

Download         Length: 207 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB X6KMY1


Antitoxin

Source ID Structure
AlphaFold DB X6KJU0

References