Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3590662..3591323 Replicon chromosome
Accession NZ_CP100475
Organism Mesorhizobium sp. C372A

Toxin (Protein)


Gene name vapC Uniprot ID V7HJQ8
Locus tag NLY42_RS17015 Protein ID WP_023682204.1
Coordinates 3590886..3591323 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID X6KNM3
Locus tag NLY42_RS17010 Protein ID WP_023668191.1
Coordinates 3590662..3590889 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY42_RS16995 (NLY42_17010) 3586060..3587094 + 1035 WP_023668188.1 ABC transporter permease -
NLY42_RS17000 (NLY42_17015) 3587108..3588265 + 1158 WP_023668189.1 ABC transporter permease -
NLY42_RS17005 (NLY42_17020) 3588313..3590517 + 2205 WP_023753563.1 ABC transporter ATP-binding protein -
NLY42_RS17010 (NLY42_17025) 3590662..3590889 + 228 WP_023668191.1 hypothetical protein Antitoxin
NLY42_RS17015 (NLY42_17030) 3590886..3591323 + 438 WP_023682204.1 PIN domain-containing protein Toxin
NLY42_RS17020 (NLY42_17035) 3591380..3591970 - 591 WP_023707714.1 transglycosylase SLT domain-containing protein -
NLY42_RS17025 (NLY42_17040) 3592188..3593726 + 1539 WP_023707716.1 trimethylamine methyltransferase family protein -
NLY42_RS17030 (NLY42_17045) 3593805..3596246 + 2442 WP_023753562.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15576.77 Da        Isoelectric Point: 6.8429

>T250572 WP_023682204.1 NZ_CP100475:3590886-3591323 [Mesorhizobium sp. C372A]
VTFLLDVNVLIALIDPAHVAHEDAHRWFQSTGHLSWATCPITENGVIRIVSNPKYPNSPGSPAVVAQIVGKLHALSGHQF
WPDEISLVGSNDIDAARILTPAQVTDSYLLGLAKARDGQLATFDRKLSTAAVKGGRSILHLIPSE

Download         Length: 438 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.34 Da        Isoelectric Point: 5.0152

>AT250572 WP_023668191.1 NZ_CP100475:3590662-3590889 [Mesorhizobium sp. C372A]
VRTTLAIDDDVLLAAKAMARQQDRSVGDVISDLARRSLRRPPTGGERNGIPLLASRPDGPMVDLEMVNALRDELP

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HJQ8

Antitoxin

Source ID Structure
AlphaFold DB X6KNM3

References