Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3562364..3563034 Replicon chromosome
Accession NZ_CP100475
Organism Mesorhizobium sp. C372A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NLY42_RS16940 Protein ID WP_023753568.1
Coordinates 3562636..3563034 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID X6J8K0
Locus tag NLY42_RS16935 Protein ID WP_023687970.1
Coordinates 3562364..3562636 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY42_RS16915 (NLY42_16930) 3557558..3558706 - 1149 WP_023753569.1 hypothetical protein -
NLY42_RS16920 (NLY42_16935) 3558793..3560361 + 1569 WP_081839900.1 acyl--CoA ligase -
NLY42_RS16925 (NLY42_16940) 3560427..3560876 - 450 WP_023673075.1 Rrf2 family transcriptional regulator -
NLY42_RS16930 (NLY42_16945) 3561137..3562123 - 987 WP_023744562.1 sulfate ABC transporter substrate-binding protein -
NLY42_RS16935 (NLY42_16950) 3562364..3562636 + 273 WP_023687970.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NLY42_RS16940 (NLY42_16955) 3562636..3563034 + 399 WP_023753568.1 type II toxin-antitoxin system VapC family toxin Toxin
NLY42_RS16945 (NLY42_16960) 3563049..3564089 - 1041 WP_023673079.1 sulfate/molybdate ABC transporter ATP-binding protein -
NLY42_RS16950 (NLY42_16965) 3564163..3565047 - 885 WP_023673080.1 sulfate ABC transporter permease subunit CysW -
NLY42_RS16955 (NLY42_16970) 3565040..3565891 - 852 WP_023687973.1 sulfate ABC transporter permease subunit CysT -
NLY42_RS16960 (NLY42_16975) 3565910..3566938 - 1029 WP_023673082.1 sulfate ABC transporter substrate-binding protein -
NLY42_RS16965 (NLY42_16980) 3567169..3567852 - 684 WP_023753567.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(17-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14179.44 Da        Isoelectric Point: 6.4544

>T250571 WP_023753568.1 NZ_CP100475:3562636-3563034 [Mesorhizobium sp. C372A]
MRFMLDTNIISDMIRNPAGKAASTAVRAGDGALCTSIVVASELRYGCARKGSAKLLAKVEQLLAELPVLPLDVPMDNEYG
ALRAELEARGQPIGHNDLFIAAHACVLGTTLVTANTAEFRRIKGLTVENWLE

Download         Length: 399 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10187.71 Da        Isoelectric Point: 5.6343

>AT250571 WP_023687970.1 NZ_CP100475:3562364-3562636 [Mesorhizobium sp. C372A]
MPQHRHSIPPPREAKLFRNNRSQAVRIPVEFELPGEKVLISRDGDRLIIEPVRKPGLVALLAQWAKEPPLGPEDDFPEIH
DAPVGPEDIF

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB X6J8K0

References