250570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3013693..3014321 Replicon chromosome
Accession NZ_CP100475
Organism Mesorhizobium sp. C372A

Toxin (Protein)


Gene name vapC Uniprot ID V7HPF9
Locus tag NLY42_RS14320 Protein ID WP_023724991.1
Coordinates 3013935..3014321 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID X6KRM4
Locus tag NLY42_RS14315 Protein ID WP_023724992.1
Coordinates 3013693..3013938 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY42_RS14285 (NLY42_14300) 3008802..3009554 - 753 WP_023669968.1 SDR family NAD(P)-dependent oxidoreductase -
NLY42_RS14290 (NLY42_14305) 3009600..3010688 - 1089 WP_023754959.1 AbrB family transcriptional regulator -
NLY42_RS14295 (NLY42_14310) 3010769..3011077 - 309 WP_023691624.1 putative quinol monooxygenase -
NLY42_RS14300 (NLY42_14315) 3011157..3011936 - 780 WP_023686180.1 SDR family oxidoreductase -
NLY42_RS14305 (NLY42_14320) 3012010..3012438 - 429 WP_023754958.1 DsrE family protein -
NLY42_RS14310 (NLY42_14325) 3012539..3013627 + 1089 WP_023754957.1 hypothetical protein -
NLY42_RS14315 (NLY42_14330) 3013693..3013938 + 246 WP_023724992.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NLY42_RS14320 (NLY42_14335) 3013935..3014321 + 387 WP_023724991.1 type II toxin-antitoxin system VapC family toxin Toxin
NLY42_RS14325 (NLY42_14340) 3014328..3015275 - 948 WP_023754956.1 cation diffusion facilitator family transporter -
NLY42_RS14330 (NLY42_14345) 3015281..3017470 - 2190 WP_023754955.1 anthranilate synthase -
NLY42_RS14335 (NLY42_14350) 3017791..3018561 + 771 WP_023695831.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14208.29 Da        Isoelectric Point: 5.6660

>T250570 WP_023724991.1 NZ_CP100475:3013935-3014321 [Mesorhizobium sp. C372A]
VTYLLDTNAVIAIIAGDEGLLALLKRHAPQDFALSAVVLHELYYGAEKSQRKVQNLARIEALQFPVLEFDRDDARHAGEI
RAGLAALGTPIGPYDALIGGQARARDLTLITRNIREFERIKDLTIETW

Download         Length: 387 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9354.49 Da        Isoelectric Point: 4.4609

>AT250570 WP_023724992.1 NZ_CP100475:3013693-3013938 [Mesorhizobium sp. C372A]
MDKAKVFWSGRSQAVRLPKEFRFEADEVSIRRHGQTVILEPLAQDWAWLDQVIGPVDDDFVQGALERQDGQDRPALDDLF
K

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HPF9

Antitoxin

Source ID Structure
AlphaFold DB X6KRM4

References