250569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1092894..1093446 Replicon chromosome
Accession NZ_CP100475
Organism Mesorhizobium sp. C372A

Toxin (Protein)


Gene name brnT Uniprot ID V7HIW4
Locus tag NLY42_RS05050 Protein ID WP_023755803.1
Coordinates 1092894..1093148 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID V7HH53
Locus tag NLY42_RS05055 Protein ID WP_023755802.1
Coordinates 1093135..1093446 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY42_RS05035 (NLY42_05065) 1088009..1088968 - 960 WP_023671388.1 ABC transporter permease -
NLY42_RS05040 (NLY42_05070) 1088985..1090571 - 1587 WP_023755805.1 ABC transporter substrate-binding protein -
NLY42_RS05045 (NLY42_05075) 1090726..1092711 - 1986 WP_023755804.1 CocE/NonD family hydrolase -
NLY42_RS05050 (NLY42_05080) 1092894..1093148 + 255 WP_023755803.1 BrnT family toxin Toxin
NLY42_RS05055 (NLY42_05085) 1093135..1093446 + 312 WP_023755802.1 BrnA antitoxin family protein Antitoxin
NLY42_RS05060 (NLY42_05090) 1093457..1094050 - 594 WP_023671383.1 nucleoside deaminase -
NLY42_RS05065 (NLY42_05095) 1094054..1094554 - 501 WP_023755801.1 ureidoglycolate lyase -
NLY42_RS05070 (NLY42_05100) 1094551..1095414 - 864 WP_023755800.1 bifunctional allantoicase/(S)-ureidoglycine aminohydrolase -
NLY42_RS05075 (NLY42_05105) 1095441..1096859 - 1419 WP_023755799.1 allantoinase PuuE -
NLY42_RS05080 (NLY42_05110) 1097044..1097418 + 375 WP_023694734.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-77)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9526.98 Da        Isoelectric Point: 6.3419

>T250569 WP_023755803.1 NZ_CP100475:1092894-1093148 [Mesorhizobium sp. C372A]
MKIVWDEPKRVTNLDSRGLDFAELDIEFFATSTVFPAKADRFKAIGEFGEIILAVIFKPLGSEAISVISMRRASRKERSV
YEQS

Download         Length: 255 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11724.24 Da        Isoelectric Point: 7.0203

>AT250569 WP_023755802.1 NZ_CP100475:1093135-1093446 [Mesorhizobium sp. C372A]
MNNHKSRVRPLTDAEEVEIQRQIVDDPDDAETTDEQLAQARPFAEVFPELFESIRRARGRPAVEKPKQVVSIRLDQDVIS
KFKATGKGWQARINEVLKNAKVG

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V7HIW4

Antitoxin

Source ID Structure
AlphaFold DB V7HH53

References