Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5718821..5719488 Replicon chromosome
Accession NZ_CP100472
Organism Mesorhizobium sp. C399B

Toxin (Protein)


Gene name vapC Uniprot ID X6IYQ3
Locus tag NLY36_RS27180 Protein ID WP_023695548.1
Coordinates 5719072..5719488 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V7HL59
Locus tag NLY36_RS27175 Protein ID WP_023670289.1
Coordinates 5718821..5719075 (+) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY36_RS27150 (NLY36_27100) 5714313..5715020 - 708 WP_023689060.1 phosphoribosylglycinamide formyltransferase -
NLY36_RS27155 (NLY36_27105) 5715017..5716096 - 1080 WP_023689059.1 phosphoribosylformylglycinamidine cyclo-ligase -
NLY36_RS27160 (NLY36_27110) 5716284..5716825 + 542 Protein_5379 CDP-alcohol phosphatidyltransferase family protein -
NLY36_RS27165 (NLY36_27115) 5716797..5717990 + 1194 WP_023695549.1 AI-2E family transporter -
NLY36_RS27170 (NLY36_27120) 5717993..5718697 + 705 WP_023689058.1 DnaA regulatory inactivator HdaA -
NLY36_RS27175 (NLY36_27125) 5718821..5719075 + 255 WP_023670289.1 plasmid stabilization protein Antitoxin
NLY36_RS27180 (NLY36_27130) 5719072..5719488 + 417 WP_023695548.1 type II toxin-antitoxin system VapC family toxin Toxin
NLY36_RS27185 (NLY36_27135) 5719796..5720056 - 261 WP_023689056.1 hypothetical protein -
NLY36_RS27190 (NLY36_27140) 5720448..5720759 - 312 WP_023689055.1 hypothetical protein -
NLY36_RS27200 (NLY36_27150) 5721067..5722251 - 1185 WP_023695547.1 NAD(P)/FAD-dependent oxidoreductase -
NLY36_RS27205 (NLY36_27155) 5722425..5722730 + 306 WP_023670294.1 ETC complex I subunit -
NLY36_RS27220 (NLY36_27170) 5723092..5723427 + 336 WP_031198108.1 hypothetical protein -
NLY36_RS27225 (NLY36_27175) 5723460..5724317 + 858 WP_198031602.1 alpha/beta hydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-123)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 14813.02 Da        Isoelectric Point: 6.0769

>T250568 WP_023695548.1 NZ_CP100472:5719072-5719488 [Mesorhizobium sp. C399B]
MILLDTNVVSEAMKPEPHQAVLAWLDNQAEETLYLSSVTLAEVLFGIEAMPAGRRKAALAETFAGVCAVFERRILPFDTE
AARHYARLAVKARAAGKGFPVPDGYIAAIASANGFHLASRDTAPFHAAGVPVIDPWQP

Download         Length: 417 bp


Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9177.42 Da        Isoelectric Point: 6.4714

>AT250568 WP_023670289.1 NZ_CP100472:5718821-5719075 [Mesorhizobium sp. C399B]
MPAVTVRNLPEATHRALRVRAALHGRSTEAEIRDILENAVRPDGRVKLGSVLADIARRAGLTNEDVEVLEQARDKAPAEP
LGFE

Download         Length: 255 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB X6IYQ3


Antitoxin

Source ID Structure
AlphaFold DB V7HL59

References